5fr3

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==X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)==
==X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)==
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<StructureSection load='5fr3' size='340' side='right' caption='[[5fr3]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='5fr3' size='340' side='right'caption='[[5fr3]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fr3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FR3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fr3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FR3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.935&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr3 OCA], [http://pdbe.org/5fr3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fr3 RCSB], [http://www.ebi.ac.uk/pdbsum/5fr3 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr3 OCA], [https://pdbe.org/5fr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fr3 RCSB], [https://www.ebi.ac.uk/pdbsum/5fr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fr3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baets, G De]]
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[[Category: Bacillus anthracis]]
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[[Category: Beerten, J]]
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[[Category: Large Structures]]
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[[Category: Brams, M]]
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[[Category: Beerten J]]
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[[Category: Durme, J van]]
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[[Category: Brams M]]
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[[Category: Gallardo, R]]
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[[Category: De Baets G]]
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[[Category: Ganesan, A]]
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[[Category: De Smet F]]
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[[Category: Kant, R van der]]
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[[Category: Gallardo R]]
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[[Category: Langenberg, T]]
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[[Category: Ganesan A]]
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[[Category: Ramakers, M]]
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[[Category: Langenberg T]]
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[[Category: Rousseau, F]]
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[[Category: Ramakers M]]
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[[Category: Schymkowitz, J]]
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[[Category: Rousseau F]]
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[[Category: Siekierska, A]]
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[[Category: Schymkowitz J]]
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[[Category: Smet, F De]]
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[[Category: Siekierska A]]
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[[Category: Ulens, C]]
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[[Category: Ulens C]]
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[[Category: Wilkinson, H]]
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[[Category: Wilkinson H]]
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[[Category: Anthrax protective antigen]]
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[[Category: Van Durme J]]
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[[Category: Toxin]]
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[[Category: Van der Kant R]]

Current revision

X-ray crystal structure of aggregation-resistant protective antigen of Bacillus anthracis (mutant S559L T576E)

PDB ID 5fr3

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