5ie1

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'''Unreleased structure'''
 
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The entry 5ie1 is ON HOLD
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==Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide==
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<StructureSection load='5ie1' size='340' side='right'caption='[[5ie1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ie1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IE1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.298&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BS:3-[2-AMINO-6-(2-METHYLPHENYL)QUINOLIN-3-YL]-N-(3,3-DIMETHYLBUTYL)PROPANAMIDE'>6BS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ie1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ie1 OCA], [https://pdbe.org/5ie1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ie1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ie1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ie1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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Authors: Jordan, J.B., Whittington, D.A., Bartberger, M.D., Sickmier, E.A., Chen, K., Cheng, Y., Judd, T.
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==See Also==
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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Description: Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Cheng, Y]]
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__TOC__
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[[Category: Chen, K]]
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</StructureSection>
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[[Category: Judd, T]]
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[[Category: Homo sapiens]]
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[[Category: Bartberger, M.D]]
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[[Category: Large Structures]]
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[[Category: Whittington, D.A]]
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[[Category: Bartberger MD]]
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[[Category: Sickmier, E.A]]
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[[Category: Chen K]]
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[[Category: Jordan, J.B]]
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[[Category: Cheng Y]]
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[[Category: Jordan JB]]
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[[Category: Judd T]]
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[[Category: Sickmier EA]]
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[[Category: Whittington DA]]

Current revision

Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide

PDB ID 5ie1

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