1gtd

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[[Image:1gtd.gif|left|200px]]
 
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{{Structure
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==NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG ID TT50) STRUCTURE OF MTH169, THE PURS SUBUNIT OF FGAM SYNTHETASE==
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|PDB= 1gtd |SIZE=350|CAPTION= <scene name='initialview01'>1gtd</scene>, resolution 2.56&Aring;
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<StructureSection load='1gtd' size='340' side='right'caption='[[1gtd]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[1gtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GTD FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02700 PurS]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gtd OCA], [https://pdbe.org/1gtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gtd RCSB], [https://www.ebi.ac.uk/pdbsum/1gtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gtd ProSAT], [https://www.topsan.org/Proteins/NESGC/1gtd TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gtd OCA], [http://www.ebi.ac.uk/pdbsum/1gtd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gtd RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PURS_METTH PURS_METTH] Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.[HAMAP-Rule:MF_01926]
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== Evolutionary Conservation ==
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'''NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG ID TT50) STRUCTURE OF MTH169, THE PURS SUBUNIT OF FGAM SYNTHETASE'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gtd_consurf.spt"</scriptWhenChecked>
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1GTD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTD OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase., Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L, Proteins. 2002 Nov 1;49(2):285-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12211007 12211007]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gtd ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Methanothermobacter thermautotrophicus]]
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[[Category: Single protein]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Batra R]]
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[[Category: Batra, R.]]
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[[Category: Christendat D]]
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[[Category: Christendat, D.]]
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[[Category: Saxild HH]]
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[[Category: Edwards, A.]]
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[[Category: Tong L]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Tong, L.]]
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[[Category: fgam synthetase,purine synthesis pathway,psi,protein structure initiative,nesg,northeast structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:50:52 2008''
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Current revision

NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG ID TT50) STRUCTURE OF MTH169, THE PURS SUBUNIT OF FGAM SYNTHETASE

PDB ID 1gtd

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