5ijd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5ijd is ON HOLD Authors: Wang, Y., Su, L., Morin, M.D., Jones, B.T., Whitby, L.R., Surakattula, M., Huang, H., Shi, H., Choi, J.H., Wang, K., Moresc...) |
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| - | '''Unreleased structure''' | ||
| - | The entry 5ijd is | + | ==The crystal structure of mouse TLR4/MD-2/lipid A complex== |
| + | <StructureSection load='5ijd' size='340' side='right'caption='[[5ijd]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ijd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hg6 5hg6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=LP4:2-DEOXY-3-O-[(3R)-3-HYDROXYTETRADECANOYL]-2-{[(3R)-3-HYDROXYTETRADECANOYL]AMINO}-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>LP4</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijd OCA], [https://pdbe.org/5ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijd RCSB], [https://www.ebi.ac.uk/pdbsum/5ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU] [https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] | |
| - | + | *[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Eptatretus burgeri]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Berger M]] |
| - | [[Category: | + | [[Category: Beutler B]] |
| - | [[Category: | + | [[Category: Boger DL]] |
| - | [[Category: | + | [[Category: Choi JH]] |
| - | [[Category: Su | + | [[Category: Huang H]] |
| - | [[Category: Surakattula | + | [[Category: Jones BT]] |
| - | [[Category: | + | [[Category: Moresco EM]] |
| - | [[Category: | + | [[Category: Morin MD]] |
| - | [[Category: | + | [[Category: Shi H]] |
| - | [[Category: | + | [[Category: Su L]] |
| + | [[Category: Surakattula M]] | ||
| + | [[Category: Wang K]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Whitby LR]] | ||
| + | [[Category: Zhan X]] | ||
| + | [[Category: Zhang H]] | ||
Current revision
The crystal structure of mouse TLR4/MD-2/lipid A complex
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Categories: Eptatretus burgeri | Large Structures | Mus musculus | Berger M | Beutler B | Boger DL | Choi JH | Huang H | Jones BT | Moresco EM | Morin MD | Shi H | Su L | Surakattula M | Wang K | Wang Y | Whitby LR | Zhan X | Zhang H
