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5ijd

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'''Unreleased structure'''
 
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The entry 5ijd is ON HOLD
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==The crystal structure of mouse TLR4/MD-2/lipid A complex==
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<StructureSection load='5ijd' size='340' side='right'caption='[[5ijd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ijd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hg6 5hg6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=LP4:2-DEOXY-3-O-[(3R)-3-HYDROXYTETRADECANOYL]-2-{[(3R)-3-HYDROXYTETRADECANOYL]AMINO}-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>LP4</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijd OCA], [https://pdbe.org/5ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijd RCSB], [https://www.ebi.ac.uk/pdbsum/5ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijd ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection.
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== Function ==
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[https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU] [https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref>
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Authors: Wang, Y., Su, L., Morin, M.D., Jones, B.T., Whitby, L.R., Surakattula, M., Huang, H., Shi, H., Choi, J.H., Wang, K., Moresco, E.M., Berger, M., Zhan, X., Zhang, H., Boger, D.L., Beutler, B.
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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Description: The crystal structure of mouse TLR4/MD-2/lipid A complex
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Zhang, H]]
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<references/>
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[[Category: Wang, Y]]
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__TOC__
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[[Category: Jones, B.T]]
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</StructureSection>
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[[Category: Choi, J.H]]
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[[Category: Eptatretus burgeri]]
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[[Category: Whitby, L.R]]
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[[Category: Large Structures]]
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[[Category: Beutler, B]]
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[[Category: Mus musculus]]
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[[Category: Wang, K]]
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[[Category: Berger M]]
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[[Category: Berger, M]]
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[[Category: Beutler B]]
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[[Category: Zhan, X]]
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[[Category: Boger DL]]
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[[Category: Huang, H]]
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[[Category: Choi JH]]
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[[Category: Su, L]]
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[[Category: Huang H]]
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[[Category: Surakattula, M]]
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[[Category: Jones BT]]
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[[Category: Boger, D.L]]
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[[Category: Moresco EM]]
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[[Category: Morin, M.D]]
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[[Category: Morin MD]]
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[[Category: Moresco, E.M]]
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[[Category: Shi H]]
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[[Category: Shi, H]]
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[[Category: Su L]]
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[[Category: Surakattula M]]
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[[Category: Wang K]]
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[[Category: Wang Y]]
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[[Category: Whitby LR]]
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[[Category: Zhan X]]
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[[Category: Zhang H]]

Current revision

The crystal structure of mouse TLR4/MD-2/lipid A complex

PDB ID 5ijd

Drag the structure with the mouse to rotate

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