1gvz

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[[Image:1gvz.jpg|left|200px]]
 
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{{Structure
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==Prostate Specific Antigen (PSA) from stallion seminal plasma==
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|PDB= 1gvz |SIZE=350|CAPTION= <scene name='initialview01'>1gvz</scene>, resolution 1.42&Aring;
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<StructureSection load='1gvz' size='340' side='right'caption='[[1gvz]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Act+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1gvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GVZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvz OCA], [https://pdbe.org/1gvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gvz RCSB], [https://www.ebi.ac.uk/pdbsum/1gvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gvz ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gvz OCA], [http://www.ebi.ac.uk/pdbsum/1gvz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gvz RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KLK2_HORSE KLK2_HORSE] Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gvz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gvz ConSurf].
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<div style="clear:both"></div>
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'''PROSTATE SPECIFIC ANTIGEN (PSA) FROM STALLION SEMINAL PLASMA'''
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Prostate-specific kallikrein, a member of the gene family of serine proteases, was initially discovered in semen and is the most useful serum marker for prostate cancer diagnosis and prognosis. We report the crystal structure at 1.42A resolution of horse prostate kallikrein (HPK). This is the first structure of a serine protease purified from seminal plasma. HPK shares extensive sequence homology with human prostate-specific antigen (PSA), including a predicted chymotrypsin-like specificity, as suggested by the presence of a serine residue at position S1 of the specificity pocket. In contrast to other kallikreins, HPK shows a structurally distinct specificity pocket. Its entrance is blocked by the kallikrein loop, suggesting a possible protective or substrate-selective role for this loop. The HPK structure seems to be in an inactivated state and further processing might be required to allow the binding of substrate molecules. Crystal soaking experiments revealed a binding site for Zn(2+) and Hg(2+), two known PSA inhibitors.
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==About this Structure==
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1GVZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GVZ OCA].
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==Reference==
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Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA., Carvalho AL, Sanz L, Barettino D, Romero A, Calvete JJ, Romao MJ, J Mol Biol. 2002 Sep 13;322(2):325-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12217694 12217694]
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[[Category: Equus caballus]]
[[Category: Equus caballus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barettino, D.]]
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[[Category: Barettino D]]
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[[Category: Calvete, J J.]]
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[[Category: Calvete JJ]]
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[[Category: Carvalho, A L.]]
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[[Category: Carvalho AL]]
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[[Category: Romao, M J.]]
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[[Category: Romao MJ]]
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[[Category: Romero, A.]]
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[[Category: Romero A]]
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[[Category: Sanz, L.]]
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[[Category: Sanz L]]
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[[Category: kallikrein]]
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[[Category: prostate specific antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:52:28 2008''
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Current revision

Prostate Specific Antigen (PSA) from stallion seminal plasma

PDB ID 1gvz

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