Glucose-fructose oxidoreductase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Glucose-fructose oxidoreductase complex with NADPH and glycerol (PDB entry [[1evj]])' scene='49/490077/Cv/1'> |
== Function == | == Function == | ||
'''Glucose-fructose oxidoreductase''' (GFOR) from the bacteria ''Zymomonas mobilis'' catalyzes the conversion of D-glucose and D-fructose to D-gluconolactone and D-glucitol (sorbitol)<ref>PMID:3356190</ref>. GFOR contains a tightly bound cofactor NADP+. | '''Glucose-fructose oxidoreductase''' (GFOR) from the bacteria ''Zymomonas mobilis'' catalyzes the conversion of D-glucose and D-fructose to D-gluconolactone and D-glucitol (sorbitol)<ref>PMID:3356190</ref>. GFOR contains a tightly bound cofactor NADP+. | ||
== Structural highlights == | == Structural highlights == | ||
| - | The biological assembly of GFOR from ''Zymomonas mobilis'' is <scene name='49/490077/Cv/ | + | The biological assembly of GFOR from ''Zymomonas mobilis'' is <scene name='49/490077/Cv/8'>homotetramer</scene>. <scene name='49/490077/Cv/9'>GFOR active site contains the cofactor NADPH</scene> and in this 3D structure the <scene name='49/490077/Cv/10'>glycerol molecule seen in the active site occupies the position of the glucose ligand</scene><ref>PMID:11705375</ref>. Water molecules shown as red spheres. |
==3D structures of glucose-fructose oxidoreductase== | ==3D structures of glucose-fructose oxidoreductase== | ||
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[[1evj]] – GFOR (mutant) + NAD<br /> | [[1evj]] – GFOR (mutant) + NAD<br /> | ||
[[1h6b]], [[1rye]] - GFOR + glycerol + NADPH<BR /> | [[1h6b]], [[1rye]] - GFOR + glycerol + NADPH<BR /> | ||
| - | [[1h6c]] - GFOR + succinate + NADPH<BR /> | + | [[1h6c]] - GFOR precursor + succinate + NADPH<BR /> |
[[1ryd]] - GFOR + glucose + NADPH<BR /> | [[1ryd]] - GFOR + glucose + NADPH<BR /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
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