Granzyme
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='1iau' size='400' side='right' caption='Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry [[1iau]])' scene='51/517375/Cv/1'> |
| - | + | == Function == | |
'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> | '''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> | ||
| - | *'''Granzyme A | + | *'''Granzyme A''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br /> |
| - | *'''Granzyme B and C''' | + | *'''Granzyme B and C''' induce cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br /> |
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | *'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | ||
| + | *'''Granzyme K''' functions in a similar way to granzyme A <ref>PMID:19059912</ref>.<br /> | ||
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | *'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | ||
| + | |||
| + | == Structural highlights == | ||
| + | The <scene name='51/517375/Cv/6'>active site</scene> of human GZMB contains the <scene name='51/517375/Cv/7'>typical serine protease catalytic triad</scene> and <scene name='51/517375/Cv/8'>oxyanion hole</scene><ref>PMID:11325591</ref>. | ||
</StructureSection> | </StructureSection> | ||
Current revision
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3D structures of granzyme
Updated on 04-April-2019
References
- ↑ Bots M, Medema JP. Granzymes at a glance. J Cell Sci. 2006 Dec 15;119(Pt 24):5011-4. PMID:17158907 doi:http://dx.doi.org/10.1242/jcs.03239
- ↑ Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. PMID:20536557 doi:http://dx.doi.org/10.1111/j.0105-2896.2010.00902.x
- ↑ Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-8. PMID:12752668
- ↑ Waterhouse NJ, Trapani JA. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. PMID:17766182 doi:http://dx.doi.org/10.1016/j.it.2007.08.001
- ↑ Bovenschen N, Quadir R, van den Berg AL, Brenkman AB, Vandenberghe I, Devreese B, Joore J, Kummer JA. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem. 2009 Feb 6;284(6):3504-12. doi: 10.1074/jbc.M806716200. Epub 2008, Dec 5. PMID:19059912 doi:http://dx.doi.org/10.1074/jbc.M806716200
- ↑ de Poot SA, Bovenschen N. Granzyme M: behind enemy lines. Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014, Jan 10. PMID:24413154 doi:http://dx.doi.org/10.1038/cdd.2013.189
- ↑ Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. Chem Biol. 2001 Apr;8(4):357-68. PMID:11325591
