Hemagglutinin-esterase
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' scene='48/484851/Cv/1' caption='Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate [[3i1l]]'> | |
== Function == | == Function == | ||
| - | '''Hemagglutinin-esterase''' (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor - a sialic acid derivative. The esterase region of the HE is responsible for the destruction of the receptor<ref>PMID:16575523</ref>. The HE is a | + | '''Hemagglutinin-esterase''' (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor - a sialic acid derivative. The esterase region of the HE is responsible for the destruction of the receptor<ref>PMID:16575523</ref>. |
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| + | == Structural highlights == | ||
| + | The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>. | ||
==3D structures of hemagglutinin-esterase== | ==3D structures of hemagglutinin-esterase== | ||
| + | [[Hemagglutinin-esterase 3D structures]] | ||
| - | + | </StructureSection> | |
| - | [[3cl4]] – bHE – bovine<br /> | ||
| - | [[3cl5]] – bHE (mutant) + receptor<br /> | ||
| - | [[3i1k]] – PtHE (mutant) – porcine torovirus<br /> | ||
| - | [[3i1l]] – PtHE (mutant) + receptor<br /> | ||
| - | [[3i26]] – BtHE – bovine torovirus<br /> | ||
| - | [[3i27]] – BtHE + receptor<br /> | ||
| - | [[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br /> | ||
| - | [[4c7w]] – mhvHE (mutant) + receptor<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
- ↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492
