1gzt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:26, 27 March 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1gzt.gif|left|200px]]
 
-
{{Structure
+
==Pseudomonas aeruginosa lectin II (PA-IIL) together with fucose==
-
|PDB= 1gzt |SIZE=350|CAPTION= <scene name='initialview01'>1gzt</scene>, resolution 1.30&Aring;
+
<StructureSection load='1gzt' size='340' side='right'caption='[[1gzt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=FUA:Ca+Binding+Site+For+Chain+D'>FUA</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
+
<table><tr><td colspan='2'>[[1gzt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZT FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [https://pdbe.org/1gzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB], [https://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzt ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzt OCA], [http://www.ebi.ac.uk/pdbsum/1gzt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gzt RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/Q9HYN5_PSEAE Q9HYN5_PSEAE]
-
 
+
== Evolutionary Conservation ==
-
'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==Overview==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzt_consurf.spt"</scriptWhenChecked>
-
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1GZT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzt ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12415289 12415289]
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
-
[[Category: Single protein]]
+
[[Category: Gilboa-Garber N]]
-
[[Category: Gilboa-Garber, N.]]
+
[[Category: Imberty A]]
-
[[Category: Imberty, A.]]
+
[[Category: Mitchell E]]
-
[[Category: Mitchell, E.]]
+
-
[[Category: fucose]]
+
-
[[Category: lectin]]
+
-
[[Category: sugar-binding protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:45 2008''
+

Current revision

Pseudomonas aeruginosa lectin II (PA-IIL) together with fucose

PDB ID 1gzt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gzt"
Personal tools