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1gzv

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[[Image:1gzv.jpg|left|200px]]
 
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{{Structure
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==The crystal structure of phosphoglucose isomerase from pig muscle complexed with 5-phosphoarabinonate==
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|PDB= 1gzv |SIZE=350|CAPTION= <scene name='initialview01'>1gzv</scene>, resolution 3.51&Aring;
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<StructureSection load='1gzv' size='340' side='right'caption='[[1gzv]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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|SITE= <scene name='pdbsite=PAR:Pa5+Binding+Site+For+Chain+A'>PAR</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PA5:5-PHOSPHOARABINONIC+ACID'>PA5</scene>
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<table><tr><td colspan='2'>[[1gzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZV FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase Glucose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 5.3.1.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PA5:5-PHOSPHOARABINONIC+ACID'>PA5</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzv OCA], [https://pdbe.org/1gzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzv RCSB], [https://www.ebi.ac.uk/pdbsum/1gzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzv ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzv OCA], [http://www.ebi.ac.uk/pdbsum/1gzv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gzv RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/G6PI_PIG G6PI_PIG] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzv ConSurf].
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<div style="clear:both"></div>
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'''THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PIG MUSCLE COMPLEXED WITH 5-PHOSPHOARABINONATE'''
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==See Also==
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*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1GZV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZV OCA].
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[[Category: Large Structures]]
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==Reference==
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Crystal structure of phosphoglucose isomerase from pig muscle and its complex with 5-phosphoarabinonate., Davies C, Muirhead H, Proteins. 2002 Dec 1;49(4):577-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12402366 12402366]
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[[Category: Glucose-6-phosphate isomerase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Davies, C.]]
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[[Category: Davies C]]
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[[Category: Muirhead, H.]]
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[[Category: Muirhead H]]
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[[Category: 5-phosphoarabinonate]]
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[[Category: aldose-ketose isomerase]]
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[[Category: cytokine]]
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[[Category: glycolytic enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:54:52 2008''
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Current revision

The crystal structure of phosphoglucose isomerase from pig muscle complexed with 5-phosphoarabinonate

PDB ID 1gzv

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