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Human rhinovirus
From Proteopedia
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== Function == | == Function == | ||
| - | '''Human rhinovirus''' (HRV) are RNA viruses. The HRV capsid is composed of 4 proteins: VP1, VP2, VP3 and VP4. The capsid structure is that of a icosahedron with 60 copies of each of its viral proteins<ref>PMID:23297263</ref>. | + | '''Human rhinovirus''' (HRV) are RNA viruses. The HRV capsid is composed of 4 proteins: VP1, VP2, VP3 and VP4. The capsid structure is that of a icosahedron with 60 copies of each of its viral proteins<ref>PMID:7915182</ref><ref>PMID:23297263</ref>. |
== Disease == | == Disease == | ||
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HRV are responsible for the majority of cold-like illnesses. | HRV are responsible for the majority of cold-like illnesses. | ||
| - | == Relevance == | ||
| - | |||
| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
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**[[1v9u]], [[3dpr]] – HRV2 VP1+VP2+VP3+VP4 + LDL-receptor class A3<br /> | **[[1v9u]], [[3dpr]] – HRV2 VP1+VP2+VP3+VP4 + LDL-receptor class A3<br /> | ||
**[[3vdd]] – HRV2 VP1+VP2+VP3+VP4 + antiviral agent<br /> | **[[3vdd]] – HRV2 VP1+VP2+VP3+VP4 + antiviral agent<br /> | ||
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| + | *Human rhinovirus B5 | ||
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| + | **[[6sk6]] – HRVB5 VP1+VP2+VP3+VP4 – Cryo EM<br /> | ||
| + | **[[6sk5]] – HRVB5 VP1+VP2+VP3+VP4 + antiviral agent – Cryo EM<br /> | ||
*Human rhinovirus 2A | *Human rhinovirus 2A | ||
**[[2m5t]] – HRV2A proteinase - NMR <br /> | **[[2m5t]] – HRV2A proteinase - NMR <br /> | ||
| + | **[[7ara]] – HRV2A proteinase + inhibitor<br /> | ||
*Human rhinovirus 3 | *Human rhinovirus 3 | ||
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*Human rhinovirus 3C | *Human rhinovirus 3C | ||
| - | **[[2xya]] – HRV3C proteinase <br /> | + | **[[2xya]], [[6sk7]] – HRV3C proteinase <br /> |
| + | **[[6ffn]], [[6ffs]], [[6ku8]] – HRV3C proteinase + inhibitor<br /> | ||
*Human rhinovirus 14 | *Human rhinovirus 14 | ||
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**[[1d3i]] – HRV14 VP1+VP2+VP3+VP4 + intercellular adhesion molecule – Cryo-EM<br /> | **[[1d3i]] – HRV14 VP1+VP2+VP3+VP4 + intercellular adhesion molecule – Cryo-EM<br /> | ||
**[[1k5m]] – HRV14 VP1+VP2/V3 of Gp120+VP3+VP4 <br /> | **[[1k5m]] – HRV14 VP1+VP2/V3 of Gp120+VP3+VP4 <br /> | ||
| + | **[[6kyz]], [[6kz0]] – HRV14 3C + antibody <br /> | ||
| + | **[[6hlt]] – HRV14 + GCP60 <br /> | ||
| + | **[[7nul]], [[7num]], [[7nuo]] – HRV14 polyprotein – Cryo-EM<br /> | ||
| + | **[[7nun]], [[7nuq]] – HRV14 polyprotein + polynucleotide – Cryo-EM<br /> | ||
| + | **[[7bg6]] – HRV14 polyprotein + RNA – Cryo-EM<br /> | ||
| + | **[[7bg7]] – HRV14 polyprotein + ICAM-1 – Cryo-EM<br /> | ||
| + | |||
| + | *Human rhinovirus C15 | ||
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| + | **[[6ppo]], [[6psf]] – HRVC15 VP1+VP2+VP3+VP4 + CDHR3 – Cryo EM<br /> | ||
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| + | *Human rhinovirus 16 | ||
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| + | **[[1aym]], [[1ayn]], [[1c8m]] – HRV16 VP1+VP2+VP3+VP4 (mutant)<br /> | ||
| + | **[[1qju]], [[1qjx]], [[1qjy]] - HRV16 VP1+VP2+VP3+VP4 + antiviral agent<br /> | ||
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}} | }} | ||
Current revision
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3D structures of human rhinovirus
Updated on 29-September-2021
References
- ↑ Oliveira MA, Zhao R, Lee WM, Kremer MJ, Minor I, Rueckert RR, Diana GD, Pevear DC, Dutko FJ, McKinlay MA, et al.. The structure of human rhinovirus 16. Structure. 1993 Sep 15;1(1):51-68. PMID:7915182
- ↑ Jacobs SE, Lamson DM, St George K, Walsh TJ. Human rhinoviruses. Clin Microbiol Rev. 2013 Jan;26(1):135-62. doi: 10.1128/CMR.00077-12. PMID:23297263 doi:http://dx.doi.org/10.1128/CMR.00077-12
