1h3z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:30, 15 May 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1h3z.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of a PWWP domain from Schizosaccharomyces Pombe==
-
|PDB= 1h3z |SIZE=350|CAPTION= <scene name='initialview01'>1h3z</scene>
+
<StructureSection load='1h3z' size='340' side='right'caption='[[1h3z]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1h3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H3Z FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3z OCA], [https://pdbe.org/1h3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h3z RCSB], [https://www.ebi.ac.uk/pdbsum/1h3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3z ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3z OCA], [http://www.ebi.ac.uk/pdbsum/1h3z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h3z RCSB]</span>
+
[https://www.uniprot.org/uniprot/PDP2_SCHPO PDP2_SCHPO]
-
}}
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h3z_consurf.spt"</scriptWhenChecked>
-
==Overview==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h3z ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
-
==About this Structure==
+
Structural variation in PWWP domains.,Slater LM, Allen MD, Bycroft M J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472<ref>PMID:12842472</ref>
-
1H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12842472 12842472]
+
</div>
 +
<div class="pdbe-citations 1h3z" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
-
[[Category: Single protein]]
+
[[Category: Allen MD]]
-
[[Category: Allen, M D.]]
+
[[Category: Bycroft M]]
-
[[Category: Bycroft, M.]]
+
[[Category: Slater LM]]
-
[[Category: Slater, L M.]]
+
-
[[Category: beta-barrel]]
+
-
[[Category: chromatin]]
+
-
[[Category: pwwp]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:57:14 2008''
+

Current revision

Solution structure of a PWWP domain from Schizosaccharomyces Pombe

PDB ID 1h3z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h3z"
Personal tools