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Integrin

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The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.
The interactions of integrin with ligands are dependent on the presence of divalent ions<ref>PMID:10961914</ref>.
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<scene name='51/516472/Cv/3'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
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<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres.
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</StructureSection>
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==3D structures of integrin==
==3D structures of integrin==
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[[Integrin 3D structures]]
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</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*IG CR3
 
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**[[1ido]] – hIG I domain + Mg – human<br />
 
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**[[1jlm]] - hIG I domain + Mn<br />
 
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*IG CD11a or IG α-L
 
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**[[1lfa]] - hIG I domain + Mn<br />
 
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**[[1zon]] - hIG I domain<br />
 
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**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br />
 
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**[[1mq9]] - hIG I domain (mutant) + Mn<br />
 
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**[[1mjn]] - hIG I domain (mutant) + Mg<br />
 
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**[[1mqa]] - hIG I domain (mutant) <br />
 
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**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR />
 
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*''IG CD11a complexes''
 
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**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
 
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**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
 
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**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
 
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**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
 
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**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
 
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**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
 
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**[[4ixd]] - hIG I domain + activator + Mg<br />
 
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**[[3f78]] - hIG I domain + anesthetic + Mg<br />
 
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**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
 
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**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
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*IG CD11b
 
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**[[1bho]] - hIG I domain + Mg<br />
 
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**[[1bhq]] - hIG I domain + Cd<br />
 
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**[[1m1u]] - hIG I domain (mutant) + Ca<br />
 
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**[[1n9z]] - hIG I domain (mutant) + Mg<br />
 
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**[[1idn]], [[1na5]] - hIG I domain<br />
 
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**[[1mf7]] - hIG I domain (mutant)
 
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*IG CD11c
 
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**[[1n3y]] - hIG I domain (mutant)
 
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*IG α-1 (CD49a)
 
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**[[1ck4]] - rIG I domain – rat<br />
 
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**[[4a0q]] - hIG I domain (mutant) + Mg<br />
 
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**[[2l8s]] - hIG transmembrane domain – NMR<BR />
 
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**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
 
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**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
 
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**[[2m32]] - hIG I domain + collagen peptide<br />
 
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*IG α-2 (CD49b)
 
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**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
 
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**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
 
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*IG α-2b
 
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**[[2k1a]] - hIG transmembrane domain – NMR<BR />
 
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*IG α-1 β-1 (CD49a-CD49b)
 
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**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
 
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**[[1pt6]] - hIG I domain + Mg<br />
 
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*IG α-2 (CD49b) β
 
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**[[1aox]] - hIG I domain (mutant) + Mg<br />
 
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**[[1s4w]], [[1dpk]] - hIG cytoplasmic domain - NMR<BR />
 
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**[[1dpq]] - hIG cytoplasmic domain (mutant) – NMR<br />
 
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*IG α-2b β-3 (CD61)
 
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**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
 
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**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
 
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**[[4cak]] – hIG – Cryo-EM<br />
 
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**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
 
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**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
 
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**[[3fc3]] – hIG (mutant) + Mg<br />
 
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**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]] – hIG headpiece + antibody + Mg<br />
 
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**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
 
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**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
 
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*IG α-4
 
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**[[4irz]] - hIG + antibody <br />
 
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*IG α-4 (CD49d) β-7
 
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**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
 
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**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
 
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*IG α-5 (CD49e) β-1 (CD29)
 
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**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
 
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**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
 
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**[[3vi3]] - hIG headpiece + antibody + Mg<br />
 
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**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
 
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*IG α-5 (CD49e) β-3 (CD61)
 
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**[[3ije]] – hIG + Ca<br />
 
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**[[1m1x]] - hIG extracellular domain + Mn<br />
 
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**[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />
 
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**[[4o02]] - hIG extracellular domain + Mn + antibody<br />
 
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**[[1u8c]] – hIG psi domain + Ca<br />
 
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**[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />
 
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**[[1l5g]] - hIG I domain + tripeptide + Mn<br />
 
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*IG α-5 β-6
 
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**[[4um8]] – hIG headpiece (mutant) + Ni<br />
 
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**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br />
 
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*IG α-L
 
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**[[4ixd]] – hIG I domain<br />
 
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**[[2m3e]] – hIG transmembrane domain - NMR<br />
 
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*IG α-M
 
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**[[3q3g]], [[3qa3]] – hIG + antibody<br />
 
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**[[4m76]] – hIG + complement C3<br />
 
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**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR />
 
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*IG α-X
 
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**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
 
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*IG α-X β-2 (CD18)
 
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**[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br />
 
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**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
 
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*IG α-V β-3
 
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**[[4g1e]], [[4g1m]] – hIG + Ni<br />
 
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*IG β-1D
 
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**[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br />
 
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*IG β-2 (CD18)
 
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**[[2p26]], [[2p28]] – hIG phe2 + phe3 domains<br />
 
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**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
 
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*IG β-3 (CD61)
 
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**[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
 
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**[[2rmz]], [[2rn0]] – hIG transmembrane domain – NMR<BR />
 
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**[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR />
 
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**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
 
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**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
 
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*IG β-4 (CD104)
 
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**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />
 
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**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
 
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**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />
 
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**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain
 
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*IG β-7
 
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**[[2brq]], [[2jf1]] – hIG cytoplasmic tail + filamin rod domain<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)

Drag the structure with the mouse to rotate

References

  1. ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
  2. ↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
  3. ↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010
  4. ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914

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