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Ketohexokinase
From Proteopedia
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| - | + | <StructureSection load='3q92' size='350' side='right' caption='Human ketohexokinase complex with ihibitor and sulfate (PDB entry [[3q92]])' scene='48/484861/Cv/1'> | |
| - | <StructureSection load=' | + | |
== Function == | == Function == | ||
| - | '''Ketohexokinase''' (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>. | + | '''Ketohexokinase''' (KHK) also known as '''hepatic fructokinase''' catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>. |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | <ref>PMID: | + | Human <scene name='48/484861/Cv/3'>KHK inhibitor interacts with the 2 monomers</scene><ref>PMID:24900346</ref>. Water molecule shown as red sphere. |
</StructureSection> | </StructureSection> | ||
| - | ==3D | + | ==3D structures of ketohexokinase== |
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[2hlz]], [[2hqq]], [[3b3l]] – hKHK – human<br /> | [[2hlz]], [[2hqq]], [[3b3l]] – hKHK – human<br /> | ||
[[2hw1]], [[3nbv]] – hKHK + AMPPNP + fructose<br /> | [[2hw1]], [[3nbv]] – hKHK + AMPPNP + fructose<br /> | ||
[[3nbw]] – hKHK + pyrazole derivative<br /> | [[3nbw]] – hKHK + pyrazole derivative<br /> | ||
| - | [[3nc2]], [[3nc9]], [[3nca]], [[3ro4]], [[3q92]], [[3qa2]], [[3qai]] – hKHK + inhibitor | + | [[3nc2]], [[3nc9]], [[3nca]], [[3ro4]], [[3q92]], [[3qa2]], [[3qai]], [[5wbm]], [[5wbo]], [[5wbp]], [[5wbq]], [[5wbr]], [[5wbz]], [[6w0n]], [[6w0w]], [[6w0x]], [[6w0y]], [[6w0z]] – hKHK + inhibitor<br /> |
| + | [[6ul7]] - hKHK + osthole + fructose <br /> | ||
| + | [[6p2d]] - KHK + ADP + fructose – mouse<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of ketohexokinase
Updated on 12-October-2021
2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai, 5wbm, 5wbo, 5wbp, 5wbq, 5wbr, 5wbz, 6w0n, 6w0w, 6w0x, 6w0y, 6w0z – hKHK + inhibitor
6ul7 - hKHK + osthole + fructose
6p2d - KHK + ADP + fructose – mouse
References
- ↑ Bais R, James HM, Rofe AM, Conyers RA. The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol. Biochem J. 1985 Aug 15;230(1):53-60. PMID:2996495
- ↑ Asipu A, Hayward BE, O'Reilly J, Bonthron DT. Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. Diabetes. 2003 Sep;52(9):2426-32. PMID:12941785
- ↑ Maryanoff BE, O'Neill JC, McComsey DF, Yabut SC, Luci DK, Jordan AD Jr, Masucci JA, Jones WJ, Abad MC, Gibbs AC, Petrounia I. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43. doi: 10.1021/ml200070g. eCollection, 2011 Jul 14. PMID:24900346 doi:http://dx.doi.org/10.1021/ml200070g
