User:Bhaskar Ganguly/MyBo HyPo
From Proteopedia
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| - | '''The ''MyBo'' HyPo | + | '''The ''MyBo'' HyPo Project''' |
---- | ---- | ||
Welcome to the ''Mycobacterium bovis''' Hypothetical Protein (''MyBo'' HyPo) Project. | Welcome to the ''Mycobacterium bovis''' Hypothetical Protein (''MyBo'' HyPo) Project. | ||
| - | The MyBo HyPo Project aims a computational characterization of all hypothetical proteins ( | + | The MyBo HyPo Project aims towards a computational characterization of all hypothetical proteins of ''M. bovis''. A Hypothetical Protein (HP) is one that is known to exist only on the basis of a corresponding gene but without any function assigned to it. Characterization of HPs of a pathogen has a potential for unraveling hitherto unknown drug and vaccine targets. ''M. bovis'' is an important veterinary pathogen of zoonotic significance, responsible for causing nearly 3% of all human cases of tuberculosis in the developing world. |
| + | |||
| + | As for now, computationally-derived models of 14 ''M. bovis'' HP UniRefs, obtained at a 90% sequence identity cut-off from all HPs of ''M. bovis'' in the UniProt Database, are being included. These models shall be updated as and when models of better quality become available. We also plan to add models of ''M. bovis'' HP sequences from other databases over the coming periods of time. | ||
- ''Bhaskar Ganguly'', Ph.D.; ''Sunil Kr. Rastogi'', Ph.D. | - ''Bhaskar Ganguly'', Ph.D.; ''Sunil Kr. Rastogi'', Ph.D. | ||
| + | |||
| + | |||
| + | ('''Note''': It may take a while for the models to load completely. Your web browser must be configured to run Java for visualization of the interactive protein models. Right click on a model to download it and for access to more options. Left click and drag a model to rotate view.) | ||
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<Structure load='A0A083W064.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083W064' scene='72/728008/A0a083w064/1' /> | <Structure load='A0A083W064.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083W064' scene='72/728008/A0a083w064/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Hypothetical arginine and alanine rich protein | ||
==== Sequence ==== | ==== Sequence ==== | ||
MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANL | MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANL | ||
| + | |||
SKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELS | SKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELS | ||
| + | |||
ERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDA | ERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDA | ||
| + | |||
ALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDE | ALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDE | ||
| + | |||
ARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVR | ARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVR | ||
| + | |||
LAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR | LAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR | ||
| Line 23: | Line 36: | ||
347 | 347 | ||
| - | ==== Localization ==== | + | ==== Predicted Localization ==== |
Cytoplasmic | Cytoplasmic | ||
| Line 31: | Line 44: | ||
---- | ---- | ||
| - | == ''M. bovis'' HP | + | == ''M. bovis'' HP A0A083W0M1 == |
| - | <Structure load=' | + | <Structure load='A0A083W0M1.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083W0M1' scene='72/728008/A0a083w0m1/1' /> |
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Conserved hypothetical alanine rich protein | ||
==== Sequence ==== | ==== Sequence ==== | ||
| - | + | MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAG | |
| - | + | ||
| - | + | AHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAA | |
| - | + | ||
| - | + | ATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAA | |
| - | + | ||
| + | LASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTG | ||
| + | |||
| + | DAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSA | ||
| + | |||
| + | KREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDAD | ||
| + | |||
| + | LGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFG | ||
| + | |||
| + | PEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLD | ||
| + | |||
| + | WLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVD | ||
| + | |||
| + | FSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG | ||
==== Length ==== | ==== Length ==== | ||
| - | + | 587 | |
| - | ==== Localization ==== | + | ==== Predicted Localization ==== |
Cytoplasmic | Cytoplasmic | ||
==== Putative Function ==== | ==== Putative Function ==== | ||
| - | + | Cell Division Inhibitor MIND | |
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A0C7DGT6 == | ||
| + | |||
| + | <Structure load='A0A0C7DGT6.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A0C7DGT6' scene='72/728008/A0a0c7dgt6/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Conserved hypothetical alanine and proline rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHAL | ||
| + | |||
| + | DADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFVQRHCETGNSVVTEVRA | ||
| + | |||
| + | AAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEALTTEGADRPTAVEVVRQ | ||
| + | |||
| + | QIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLASAPRAHFEIPDDLGPGRQPSPAS | ||
| + | |||
| + | VPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDFGSAPGDGSATPAGVGSAGGFGDAG | ||
| + | |||
| + | GTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGDPLAADNPPGAVDPFAEDAADNADDG | ||
| + | |||
| + | DDAHPEEAGEAAEPKEATEPDEADEVDDADESVPAERAQDVAEEATLPPVAEPPPPAAPP | ||
| + | |||
| + | VAEPPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP | ||
| + | |||
| + | ==== Length ==== | ||
| + | 467 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Cytoplasmic | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Undetermined | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083VPW0 == | ||
| + | |||
| + | <Structure load='A0A083VPW0.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083VPW0' scene='72/728008/A0a083vpw0/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Conserved hypothetical alanine rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MVAADLPPGRWSAVLVGAWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQG | ||
| + | |||
| + | RTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVL | ||
| + | |||
| + | ASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANG | ||
| + | |||
| + | FNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACS | ||
| + | |||
| + | QPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRL | ||
| + | |||
| + | RRLGNRLRPGW | ||
| + | |||
| + | ==== Length ==== | ||
| + | 311 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Rhamnosidase | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083VTH6 == | ||
| + | |||
| + | <Structure load='A0A083VTH6.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083VTH6' scene='72/728008/A0a083vth6/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Hypothetical alanine and valine rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDAL | ||
| + | |||
| + | RSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVV | ||
| + | |||
| + | VEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAAL | ||
| + | |||
| + | AAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAG | ||
| + | |||
| + | VALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPA | ||
| + | |||
| + | DPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAG | ||
| + | |||
| + | HQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG | ||
| + | |||
| + | ==== Length ==== | ||
| + | 404 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Photosystem II protein PsbP | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083VUK1 == | ||
| + | |||
| + | <Structure load='A0A083VUK1.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083VUK1' scene='72/728008/A0a083vuk1/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Hypothetical proline rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVID | ||
| + | |||
| + | AAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHH | ||
| + | |||
| + | SKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASV | ||
| + | |||
| + | LGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGV | ||
| + | |||
| + | PQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP | ||
| + | |||
| + | ==== Length ==== | ||
| + | 281 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Transcriptional activator | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083W378 == | ||
| + | |||
| + | <Structure load='A0A083W378.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083W378' scene='72/728008/A0a083w378/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Conserved hypothetical proline rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MATGARPALGLSIGVTNLAAVAADHSITRKPVLTLYRQRPPEVGVPSENPRLDEPGLVIT | ||
| + | |||
| + | DFVDRVGDSVGIVAADGSVYRSEALVADALLALAYTATGGRALPGSVTVTYPAHWGPAAV | ||
| + | |||
| + | AALDSALRRASEWSHGTSSTAQPLSLLPDAAAALYAIRADPGIPARGIVAVCDFGGSGTG | ||
| + | |||
| + | ITLVDAADEYRPVAATVRHQAFSGDLIDQSLLSYVMSELPGTGAFDPAGTSAIGSLTKLR | ||
| + | |||
| + | IECRKAKERLSSSTVTTLTDALGGDIRLTRNELEDTIRDSLDSVGRALEQTLARSGIRTA | ||
| + | |||
| + | ELVAIVSVGGGANIPAVTTTLSGRFCVPVVRTPRPQLTAAFGGALWAARRPGDTSATVLT | ||
| + | |||
| + | AVTSATATAPADAPASVLQPALAWSEADEDSHIGPAPGYTAARPSLSFDHDAHAEPEPKS | ||
| + | |||
| + | PPIPWYRLPAVIITGTTVAVLLVGAAVAIGLSTGDQPTAPGTPQRPGVTTTAAPPPSPAP | ||
| + | |||
| + | ASDGPTTEPAPPVQAPATGGPAPPLQQPLPPPPTTTNTQPAVTTDVITPAPTTPASAPPA | ||
| + | |||
| + | TTQPPATTQPPATTSPSPPPIPPIPPIPEIPQLPPGIPQVPGIGQFSAISGS | ||
| + | |||
| + | ==== Length ==== | ||
| + | 592 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Chaperone (DnaK-like) | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083WED4 == | ||
| + | |||
| + | <Structure load='A0A083WED4.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083WED4' scene='72/728008/A0a083wed4/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Alanine and proline rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLA | ||
| + | |||
| + | TALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITP | ||
| + | |||
| + | AAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQV | ||
| + | |||
| + | PQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP | ||
| + | |||
| + | ==== Length ==== | ||
| + | 227 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | snRNP assembly (human gemin 1-like) | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A093N4V5 == | ||
| + | |||
| + | <Structure load='A0A093N4V5.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A093N4V5' scene='72/728008/A0a093n4v5/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Hypothetical glycine rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MAFVDLRYPWCRGDGWISPPVVAVALGWAMRRKPFSRFNEYVGSASNTCWFARALELRTL | ||
| + | |||
| + | LIR | ||
| + | |||
| + | ==== Length ==== | ||
| + | 63 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Transcriptional repressor (KorB-like) | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A0C7DM56 == | ||
| + | |||
| + | <Structure load='A0A0C7DM56.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A0C7DM56' scene='72/728008/A0a0c7dm56/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Alanine and arginine and proline rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTFAVTPVVEYEPPPRNIP | ||
| + | |||
| + | PCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRLRQAGTFADAALRRVLEVI | ||
| + | |||
| + | DRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRRIRLTPAGPDTADTAAEVFGT | ||
| + | |||
| + | YSRGDRIHAIACRVEQRPAGNETRWLMVALHIG | ||
| + | |||
| + | ==== Length ==== | ||
| + | 213 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Outer Membrane | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Palmitoyl CoA hydrolase | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A0C7DHL0 == | ||
| + | |||
| + | <Structure load='A0A0C7DHL0.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A0C7DHL0' scene='72/728008/A0a0c7dhl0/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Conserved hypothetical alanine rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAINKTMPSIESLVSDGLPG | ||
| + | |||
| + | VKAALTRTASNMNAAADVYAKTDQSLGTSLSQYAFGSSGEGLAGVASVGGQPSQATQLLS | ||
| + | |||
| + | TPVSQVTTQLGETAAELAPRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSA | ||
| + | |||
| + | QGGSGPMPAQLASAEKPATEQAEPVHEVTNDDQGDQGDVQPAEVVAAARDEGAGASPGQQ | ||
| + | |||
| + | PGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPSTTTTL | ||
| + | |||
| + | ==== Length ==== | ||
| + | 280 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Secreted | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | ESX-1 secretion-associated protein EspB | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083VPS0 == | ||
| + | |||
| + | <Structure load='A0A083VPS0.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083VPS0' scene='72/728006/Mybo_hp_a0a083vps0/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Alanine and proline rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSA | ||
| + | |||
| + | AALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPS | ||
| + | |||
| + | AVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVI | ||
| + | |||
| + | RAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDP | ||
| + | |||
| + | LTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMAD | ||
| + | |||
| + | HAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWE | ||
| + | |||
| + | EMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGG | ||
| + | |||
| + | PLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAA | ||
| + | |||
| + | KPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPG | ||
| + | |||
| + | EHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRS | ||
| + | |||
| + | LSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQ | ||
| + | |||
| + | YGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPW | ||
| + | |||
| + | GQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQR | ||
| + | |||
| + | ALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIR | ||
| + | |||
| + | RGVLRQ | ||
| + | |||
| + | ==== Length ==== | ||
| + | 846 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Secreted | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Tuberculosis necrotizing toxin | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083VYR3 == | ||
| + | |||
| + | <Structure load='A0A083VYR3.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083VYR3' scene='72/728008/A0a083vyr3/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Conserved hypothetical alanine rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAA | ||
| + | |||
| + | RDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRC | ||
| + | |||
| + | DGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAV | ||
| + | |||
| + | AAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA | ||
| + | |||
| + | ==== Length ==== | ||
| + | 235 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Secreted | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Heme bromoperoxidase | ||
| + | |||
| + | ---- | ||
| + | |||
| + | == ''M. bovis'' HP A0A083W2L5 == | ||
| + | |||
| + | <Structure load='A0A083W2L5.pdb' size='300' frame='true' align='right' caption='''M. bovis'' HP A0A083W2L5' scene='72/728008/A0a083w2l5/1' /> | ||
| + | |||
| + | ==== UniProt Description ==== | ||
| + | Glycine rich protein | ||
| + | |||
| + | ==== Sequence ==== | ||
| + | MEEVPTGPPAMGHRACGGQKAAFPTRMNSGVEKMYKNSIAIAIGTLTMAVEFSMVSANAE | ||
| + | |||
| + | PAPPPGQDPHMPNSAMGYCPGGGFGGITGWGYCDGIRYPDGSYWHQVRVPAPFVGTTLTL | ||
| + | |||
| + | SCVIDDGSPVPPLAAPGSCGGGA | ||
| + | |||
| + | ==== Length ==== | ||
| + | 143 | ||
| + | |||
| + | ==== Predicted Localization ==== | ||
| + | Secreted | ||
| + | |||
| + | ==== Putative Function ==== | ||
| + | Type 2 secretory system protein (major Pseudopilin-like) | ||
---- | ---- | ||
Current revision
The MyBo HyPo Project
Welcome to the Mycobacterium bovis' Hypothetical Protein (MyBo HyPo) Project.
The MyBo HyPo Project aims towards a computational characterization of all hypothetical proteins of M. bovis. A Hypothetical Protein (HP) is one that is known to exist only on the basis of a corresponding gene but without any function assigned to it. Characterization of HPs of a pathogen has a potential for unraveling hitherto unknown drug and vaccine targets. M. bovis is an important veterinary pathogen of zoonotic significance, responsible for causing nearly 3% of all human cases of tuberculosis in the developing world.
As for now, computationally-derived models of 14 M. bovis HP UniRefs, obtained at a 90% sequence identity cut-off from all HPs of M. bovis in the UniProt Database, are being included. These models shall be updated as and when models of better quality become available. We also plan to add models of M. bovis HP sequences from other databases over the coming periods of time. - Bhaskar Ganguly, Ph.D.; Sunil Kr. Rastogi, Ph.D.
(Note: It may take a while for the models to load completely. Your web browser must be configured to run Java for visualization of the interactive protein models. Right click on a model to download it and for access to more options. Left click and drag a model to rotate view.)
M. bovis HP A0A083W064
|
UniProt Description
Hypothetical arginine and alanine rich protein
Sequence
MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANL
SKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELS
ERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDA
ALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDE
ARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVR
LAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR
Length
347
Predicted Localization
Cytoplasmic
Putative Function
Arginine decarboxylase
M. bovis HP A0A083W0M1
|
UniProt Description
Conserved hypothetical alanine rich protein
Sequence
MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAG
AHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAA
ATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAA
LASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTG
DAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSA
KREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDAD
LGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFG
PEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLD
WLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVD
FSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG
Length
587
Predicted Localization
Cytoplasmic
Putative Function
Cell Division Inhibitor MIND
M. bovis HP A0A0C7DGT6
|
UniProt Description
Conserved hypothetical alanine and proline rich protein
Sequence
MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHAL
DADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFVQRHCETGNSVVTEVRA
AAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEALTTEGADRPTAVEVVRQ
QIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLASAPRAHFEIPDDLGPGRQPSPAS
VPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDFGSAPGDGSATPAGVGSAGGFGDAG
GTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGDPLAADNPPGAVDPFAEDAADNADDG
DDAHPEEAGEAAEPKEATEPDEADEVDDADESVPAERAQDVAEEATLPPVAEPPPPAAPP
VAEPPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP
Length
467
Predicted Localization
Cytoplasmic
Putative Function
Undetermined
M. bovis HP A0A083VPW0
|
UniProt Description
Conserved hypothetical alanine rich protein
Sequence
MVAADLPPGRWSAVLVGAWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQG
RTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVL
ASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANG
FNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACS
QPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRL
RRLGNRLRPGW
Length
311
Predicted Localization
Outer Membrane
Putative Function
Rhamnosidase
M. bovis HP A0A083VTH6
|
UniProt Description
Hypothetical alanine and valine rich protein
Sequence
MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDAL
RSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVV
VEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAAL
AAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAG
VALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPA
DPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAG
HQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG
Length
404
Predicted Localization
Outer Membrane
Putative Function
Photosystem II protein PsbP
M. bovis HP A0A083VUK1
|
UniProt Description
Hypothetical proline rich protein
Sequence
MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVID
AAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHH
SKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASV
LGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGV
PQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP
Length
281
Predicted Localization
Outer Membrane
Putative Function
Transcriptional activator
M. bovis HP A0A083W378
|
UniProt Description
Conserved hypothetical proline rich protein
Sequence
MATGARPALGLSIGVTNLAAVAADHSITRKPVLTLYRQRPPEVGVPSENPRLDEPGLVIT
DFVDRVGDSVGIVAADGSVYRSEALVADALLALAYTATGGRALPGSVTVTYPAHWGPAAV
AALDSALRRASEWSHGTSSTAQPLSLLPDAAAALYAIRADPGIPARGIVAVCDFGGSGTG
ITLVDAADEYRPVAATVRHQAFSGDLIDQSLLSYVMSELPGTGAFDPAGTSAIGSLTKLR
IECRKAKERLSSSTVTTLTDALGGDIRLTRNELEDTIRDSLDSVGRALEQTLARSGIRTA
ELVAIVSVGGGANIPAVTTTLSGRFCVPVVRTPRPQLTAAFGGALWAARRPGDTSATVLT
AVTSATATAPADAPASVLQPALAWSEADEDSHIGPAPGYTAARPSLSFDHDAHAEPEPKS
PPIPWYRLPAVIITGTTVAVLLVGAAVAIGLSTGDQPTAPGTPQRPGVTTTAAPPPSPAP
ASDGPTTEPAPPVQAPATGGPAPPLQQPLPPPPTTTNTQPAVTTDVITPAPTTPASAPPA
TTQPPATTQPPATTSPSPPPIPPIPPIPEIPQLPPGIPQVPGIGQFSAISGS
Length
592
Predicted Localization
Outer Membrane
Putative Function
Chaperone (DnaK-like)
M. bovis HP A0A083WED4
|
UniProt Description
Alanine and proline rich protein
Sequence
MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQLISSAANAPQILQNLA
TALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAPALTPSIPGVNAPIPGITP
AAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASVPGVPSAKVDLPQLPYLPLQV
PQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP
Length
227
Predicted Localization
Outer Membrane
Putative Function
snRNP assembly (human gemin 1-like)
M. bovis HP A0A093N4V5
|
UniProt Description
Hypothetical glycine rich protein
Sequence
MAFVDLRYPWCRGDGWISPPVVAVALGWAMRRKPFSRFNEYVGSASNTCWFARALELRTL
LIR
Length
63
Predicted Localization
Outer Membrane
Putative Function
Transcriptional repressor (KorB-like)
M. bovis HP A0A0C7DM56
|
UniProt Description
Alanine and arginine and proline rich protein
Sequence
MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTFAVTPVVEYEPPPRNIP
PCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRLRQAGTFADAALRRVLEVI
DRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRRIRLTPAGPDTADTAAEVFGT
YSRGDRIHAIACRVEQRPAGNETRWLMVALHIG
Length
213
Predicted Localization
Outer Membrane
Putative Function
Palmitoyl CoA hydrolase
M. bovis HP A0A0C7DHL0
|
UniProt Description
Conserved hypothetical alanine rich protein
Sequence
MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAINKTMPSIESLVSDGLPG
VKAALTRTASNMNAAADVYAKTDQSLGTSLSQYAFGSSGEGLAGVASVGGQPSQATQLLS
TPVSQVTTQLGETAAELAPRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSA
QGGSGPMPAQLASAEKPATEQAEPVHEVTNDDQGDQGDVQPAEVVAAARDEGAGASPGQQ
PGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPSTTTTL
Length
280
Predicted Localization
Secreted
Putative Function
ESX-1 secretion-associated protein EspB
M. bovis HP A0A083VPS0
|
UniProt Description
Alanine and proline rich protein
Sequence
MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSA
AALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPS
AVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVI
RAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDP
LTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMAD
HAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWE
EMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGG
PLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAA
KPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPG
EHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRS
LSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQ
YGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPW
GQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQR
ALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIR
RGVLRQ
Length
846
Predicted Localization
Secreted
Putative Function
Tuberculosis necrotizing toxin
M. bovis HP A0A083VYR3
|
UniProt Description
Conserved hypothetical alanine rich protein
Sequence
MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAA
RDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRC
DGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAV
AAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA
Length
235
Predicted Localization
Secreted
Putative Function
Heme bromoperoxidase
M. bovis HP A0A083W2L5
|
UniProt Description
Glycine rich protein
Sequence
MEEVPTGPPAMGHRACGGQKAAFPTRMNSGVEKMYKNSIAIAIGTLTMAVEFSMVSANAE
PAPPPGQDPHMPNSAMGYCPGGGFGGITGWGYCDGIRYPDGSYWHQVRVPAPFVGTTLTL
SCVIDDGSPVPPLAAPGSCGGGA
Length
143
Predicted Localization
Secreted
Putative Function
Type 2 secretory system protein (major Pseudopilin-like)
