Mannose-binding protein
From Proteopedia
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| - | + | <StructureSection load='1kzb' size='400' side='right' scene='48/487540/Cv/1' caption='Rat mannose-binding protein fragment complex with mannose and Ca+2 ion (green), [[1kzb]]'> | |
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== Function == | == Function == | ||
'''Mannose-binding protein''' (MBL) or '''Mannose-binding lectin''' or '''Mannan-binding lectin''' is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen<ref>PMID:14666735</ref>. | '''Mannose-binding protein''' (MBL) or '''Mannose-binding lectin''' or '''Mannan-binding lectin''' is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen<ref>PMID:14666735</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | MBL active site contains Ca+2 ion which coordinates with the mannose<ref>PMID:11850428</ref>. | + | <scene name='48/487540/Cv/3'>MBL active site contains Ca+2 ion which coordinates with the mannose</scene><ref>PMID:11850428</ref>. |
| - | + | </StructureSection> | |
==3D structures of mannose-binding protein== | ==3D structures of mannose-binding protein== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *'''mannose-binding protein''' | + | *'''mannose-binding protein-a''' |
| - | **[[1ytt]], [[1kwt]], [[1nt0]] - rMBL fragment - rat<br /> | ||
| - | **[[1kmb]], [[1fif]] - rMBL fragment (mutant)<br /> | ||
**[[1hup]] – hMBL – human<br /> | **[[1hup]] – hMBL – human<br /> | ||
| + | **[[1ytt]], [[1kwt]], [[1buu]], [[1rtm]] - rMBL fragment - rat<br /> | ||
| + | **[[1kmb]], [[1fif]], [[1afd]], [[2kmb]] - rMBL fragment (mutant)<br /> | ||
| + | **[[1msb]] - rMBL lectin domain<br /> | ||
**[[3a0c]] – PcMBL – ''Polygonatum cyrtonema''<br /> | **[[3a0c]] – PcMBL – ''Polygonatum cyrtonema''<br /> | ||
**[[4akd]] – MBL – ''Artocarpus integer''<br /> | **[[4akd]] – MBL – ''Artocarpus integer''<br /> | ||
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**[[2y1s]] – MaMBL – ''Microcystis aeruginosa'' - NMR<br /> | **[[2y1s]] – MaMBL – ''Microcystis aeruginosa'' - NMR<br /> | ||
| - | *Mannose-binding protein complex with sugar | + | *Mannose-binding protein-a complex with sugar |
**[[1rdi]], [[1rdj]], [[1rdk]], [[1rdl]], [[1rdm]], [[1rdn]], [[1rdo]], [[1kwu]], [[1kwv]], [[1kww]], [[1kwx]] – rMBL fragment + monosaccharide <br /> | **[[1rdi]], [[1rdj]], [[1rdk]], [[1rdl]], [[1rdm]], [[1rdn]], [[1rdo]], [[1kwu]], [[1kwv]], [[1kww]], [[1kwx]] – rMBL fragment + monosaccharide <br /> | ||
| - | **[[1fih]] - rMBL fragment (mutant) + monosaccharide<br /> | + | **[[1fih]], [[1afa]], [[1afb]], [[1bch]], [[1bcj]] - rMBL fragment (mutant) + monosaccharide<br /> |
**[[1kwy]], [[1kx1]], [[1kza]], [[1kzd]], [[1kze]] - rMBL fragment + bisaccharide<br /> | **[[1kwy]], [[1kx1]], [[1kza]], [[1kzd]], [[1kze]] - rMBL fragment + bisaccharide<br /> | ||
**[[1kwz]], [[1kx0]] - rMBL fragment (mutant) + bisaccharide<br /> | **[[1kwz]], [[1kx0]] - rMBL fragment (mutant) + bisaccharide<br /> | ||
**[[1kzb]], [[1kzc]] - rMBL fragment + mannose<br /> | **[[1kzb]], [[1kzc]] - rMBL fragment + mannose<br /> | ||
| + | **[[2msb]] - rMBL fragment + oligosaccharide<br /> | ||
| + | **[[3kmb]], [[4kmb]] - rMBL fragment (mutant) + oligosaccharide<br /> | ||
**[[1qmo]] – MBL + mannose – bean<br /> | **[[1qmo]] – MBL + mannose – bean<br /> | ||
**[[2chh]] – MBL + alpha-mannose + beta-mannose – ''Ralstonia solanacearum''<br /> | **[[2chh]] – MBL + alpha-mannose + beta-mannose – ''Ralstonia solanacearum''<br /> | ||
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**[[1zhs]] – MvMBL + ManGlcNac<br /> | **[[1zhs]] – MvMBL + ManGlcNac<br /> | ||
**[[2yhh]] – MaMBL + alpha-mannose - NMR<br /> | **[[2yhh]] – MaMBL + alpha-mannose - NMR<br /> | ||
| + | |||
| + | *Mannose-binding protein-c | ||
| + | |||
| + | **[[1bvr]] - rMBL subtilisin fragment<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of mannose-binding protein
Updated on 03-September-2020
References
- ↑ Nakagawa T, Ma BY, Uemura K, Oka S, Kawasaki N, Kawasaki T. Role of mannan-binding protein, MBP, in innate immunity. Anticancer Res. 2003 Nov-Dec;23(6a):4467-71. PMID:14666735
- ↑ Carlsson M, Sjoholm AG, Eriksson L, Thiel S, Jensenius JC, Segelmark M, Truedsson L. Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship. Clin Exp Immunol. 2005 Feb;139(2):306-13. PMID:15654829 doi:http://dx.doi.org/10.1111/j.1365-2249.2004.02690.x
- ↑ Turner MW. The role of mannose-binding lectin in health and disease. Mol Immunol. 2003 Nov;40(7):423-9. PMID:14568388
- ↑ Ng KK, Kolatkar AR, Park-Snyder S, Feinberg H, Clark DA, Drickamer K, Weis WI. Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J Biol Chem. 2002 May 3;277(18):16088-95. Epub 2002 Feb 15. PMID:11850428 doi:10.1074/jbc.M200493200
