1hf9

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[[Image:1hf9.jpg|left|200px]]
 
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{{Structure
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==C-Terminal Coiled-Coil Domain from Bovine IF1==
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|PDB= 1hf9 |SIZE=350|CAPTION= <scene name='initialview01'>1hf9</scene>
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<StructureSection load='1hf9' size='340' side='right'caption='[[1hf9]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1hf9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HF9 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf9 OCA], [https://pdbe.org/1hf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hf9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf9 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf9 OCA], [http://www.ebi.ac.uk/pdbsum/1hf9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hf9 RCSB]</span>
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[https://www.uniprot.org/uniprot/ATIF1_BOVIN ATIF1_BOVIN] Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.<ref>PMID:7397110</ref> <ref>PMID:10831597</ref> <ref>PMID:18687699</ref> <ref>PMID:21192948</ref> <ref>PMID:12923572</ref> <ref>PMID:17895376</ref>
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}}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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'''C-TERMINAL COILED-COIL DOMAIN FROM BOVINE IF1'''
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==Overview==
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Bovine IF(1) is a basic, 84 amino acid residue protein that inhibits the hydrolytic action of the F(1)F(0) ATP synthase in mitochondria under anaerobic conditions. Its oligomerization state is dependent on pH. At a pH value below 6.5 it forms an active dimer. At higher pH values, two dimers associate to form an inactive tetramer. Here, we present the solution structure of a C-terminal fragment of IF(1) (44-84) containing all five of the histidine residues present in the sequence. Most unusually, the molecule forms an anti-parallel coiled-coil in which three of the five histidine residues occupy key positions at the dimer interface.
Bovine IF(1) is a basic, 84 amino acid residue protein that inhibits the hydrolytic action of the F(1)F(0) ATP synthase in mitochondria under anaerobic conditions. Its oligomerization state is dependent on pH. At a pH value below 6.5 it forms an active dimer. At higher pH values, two dimers associate to form an inactive tetramer. Here, we present the solution structure of a C-terminal fragment of IF(1) (44-84) containing all five of the histidine residues present in the sequence. Most unusually, the molecule forms an anti-parallel coiled-coil in which three of the five histidine residues occupy key positions at the dimer interface.
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==About this Structure==
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Solution structure of a C-terminal coiled-coil domain from bovine IF(1): the inhibitor protein of F(1) ATPase.,Gordon-Smith DJ, Carbajo RJ, Yang JC, Videler H, Runswick MJ, Walker JE, Neuhaus D J Mol Biol. 2001 Apr 27;308(2):325-39. PMID:11327770<ref>PMID:11327770</ref>
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1HF9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF9 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of a C-terminal coiled-coil domain from bovine IF(1): the inhibitor protein of F(1) ATPase., Gordon-Smith DJ, Carbajo RJ, Yang JC, Videler H, Runswick MJ, Walker JE, Neuhaus D, J Mol Biol. 2001 Apr 27;308(2):325-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11327770 11327770]
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</div>
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<div class="pdbe-citations 1hf9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Carbajo, R J.]]
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[[Category: Carbajo RJ]]
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[[Category: Gordon-Smith, D J.]]
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[[Category: Gordon-Smith DJ]]
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[[Category: Neuhaus, D.]]
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[[Category: Neuhaus D]]
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[[Category: Runswick, M J.]]
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[[Category: Runswick MJ]]
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[[Category: Videler, H.]]
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[[Category: Videler H]]
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[[Category: Walker, J E.]]
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[[Category: Walker JE]]
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[[Category: Yang, J C.]]
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[[Category: Yang J-C]]
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[[Category: f1 atpase inhibitor]]
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[[Category: mitochondrion]]
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[[Category: transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:03:53 2008''
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Current revision

C-Terminal Coiled-Coil Domain from Bovine IF1

PDB ID 1hf9

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