NAD(P) transhydrogenase

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<StructureSection load='1u28' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry [[1u28]])' scene=''>
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<StructureSection load='' size='450' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>
'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.
'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.
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* Domain II is a membrane-spanning domain.<br />
* Domain II is a membrane-spanning domain.<br />
* Domain III binds NADP(+)/NADPH.<br />
* Domain III binds NADP(+)/NADPH.<br />
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PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains NAD in domain I and NADP in domain III<ref>PMID:15323555</ref>.
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PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/6'>NAD in domain I</scene> and <scene name='57/571286/Cv/7'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules are shown as red spheres.
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</StructureSection>
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==3D structures of NAD(P) transhydrogenase==
==3D structures of NAD(P) transhydrogenase==
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[[NAD(P) transhydrogenase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*NAD(P) transhydrogenase domain I
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**[[1l7d]] – RrPTH domain I – ''Rhodospirillum rubrum'' <br />
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**[[1l7e]] – RrPTH domain I + NAD <br />
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**[[1x13]] – EcPTH domain I – ''Escherichia coli'' <br />
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**[[1x14]], [[1x15]] – EcPTH domain I + NAD <br />
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**[[4dio]] – PTH domain I – ''Sinorhizobium meliloti''<br />
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*PTH domain II
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**[[4o93]], [[4o9p]], [[4o9t]], [[4o9u]] – TtPTH domain II – ''Thermus thermophilus''<br />
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*NAD(P) transhydrogenase domain III
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**[[1e3t]] – RrPTH domain III + NADP - NMR<br />
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**[[1pno]] – RrPTH domain III + NADP <br />
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**[[1pnq]] – RrPTH domain III + NADPH <br />
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**[[1d4o]] – bPTH domain III + NADP - bovine<br />
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**[[1djl]], [[1u31]] – hPTH domain III + NADP - human<br />
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**[[1pt9]] – hPTH domain III + NADP analog<br />
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*NAD(P) transhydrogenase domain I+III
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**[[1hzz]], [[1u28]], [[1u2d]], [[1xlt]] – RrPTH domain I+III + NADP + NAD<br />
 
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**[[1f8g]] – RrPTH domain I+III + NAD<br />
 
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**[[1nm5]], [[2fr8]], [[2fsv]] – RrPTH domain I+III (mutant) + NADP + NAD<br />
 
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**[[1ptj]], [[1u2g]], [[2frd]], [[2oo5]] – RrPTH domain I+III + NADP + NAD derivative<br />
 
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**[[2oor]] – RrPTH domain I+III + NADP derivative + NAD<br />
 
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**[[2bru]] – EcPTH domain I+III + NADP + NAD - NMR<br />
 
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**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry 1u2d)

Drag the structure with the mouse to rotate

References

  1. ↑ Jackson JB. Proton translocation by transhydrogenase. FEBS Lett. 2003 Jun 12;545(1):18-24. PMID:12788487
  2. ↑ Mather OC, Singh A, van Boxel GI, White SA, Jackson JB. Active-site conformational changes associated with hydride transfer in proton-translocating transhydrogenase. Biochemistry. 2004 Aug 31;43(34):10952-64. PMID:15323555 doi:10.1021/bi0497594

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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