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Netrin
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='4ove' size=' | + | <StructureSection load='4ove' size='350' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene='' pspeed='8'> |
== Function == | == Function == | ||
'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | '''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The N-terminal of netrin-1 is homologous to the N-terminal | + | The N-terminal of netrin-1 is homologous to the N-terminal type I domain of laminin (LN) followed by 3 cysteine-rich epidermal growth factor repeats. |
| - | + | *<scene name='70/705761/Cv/3'>Ca coordination site</scene>. Water molecules are shown as red spheres. | |
| + | *<scene name='70/705761/Cv/4'>Cl coordination site</scene>. | ||
</StructureSection> | </StructureSection> | ||
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*Netrin-1 | *Netrin-1 | ||
| + | **[[7ne1]] – hNet1 V-VI domains 39-453 + neogenin - human<BR /> | ||
| + | **[[7ne0]] – hNet1 V-VI domains + neogenin + RGMB<BR /> | ||
| + | **[[7ndg]] – hNet1 V-VI domains + neogenin + RGMB – Cryo EM<BR /> | ||
| + | **[[4urt]] – hNet1 V-VI domains + hNet receptor DCC fourth fibronectin type FN5-FN6 domains <BR /> | ||
| + | **[[6fkq]] – hNet1 V-VI domains + draxin peptide<BR /> | ||
**[[4ove]] – mNet1 – mouse<BR /> | **[[4ove]] – mNet1 – mouse<BR /> | ||
| - | **[[4plm]] – cNet1 LN-LE3 domains – chicken<BR /> | + | **[[4plm]], [[7ler]] – cNet1 LN-LE3 domains 26-457 – chicken<BR /> |
**[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br /> | **[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br /> | ||
**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | ||
| - | **[[ | + | **[[7lrf]] – cNet1 LN-LE3 domains + SOS<br /> |
| + | |||
| + | *Netrin-4 | ||
| + | |||
| + | **[[4wnx]] – mNet4<BR /> | ||
| + | |||
| + | *Netrin-G1 | ||
| + | |||
| + | **[[3zyj]] – hNetG1 LAM + EGF1 domains (mutant) + leucine-rich repeat-containing protein<BR /> | ||
*Netrin-G2 | *Netrin-G2 | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of netrin
Updated on 13-July-2023
References
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Ylivinkka I, Hu Y, Chen P, Rantanen V, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiainen M. Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion. J Cell Sci. 2013 Jun 1;126(Pt 11):2459-69. doi: 10.1242/jcs.120022. Epub 2013 Apr, 2. PMID:23549787 doi:http://dx.doi.org/10.1242/jcs.120022
- ↑ Layne K, Ferro A, Passacquale G. Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit? Cardiovasc Res. 2015 Sep 1;107(4):410-9. doi: 10.1093/cvr/cvv201. Epub 2015 Jul, 24. PMID:26209250 doi:http://dx.doi.org/10.1093/cvr/cvv201
