Netrin receptor
From Proteopedia
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== Disease == | == Disease == | ||
| - | + | DCC gene is deleted in most colorectal cancer patients as well as in other cancers<ref>PMID:15956977</ref>. | |
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== Structural highlights == | == Structural highlights == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Netrin receptor DCC | + | *Netrin receptor DCC; domains – ectodomain 25-374; FN1 419-524; FN2 528-620; FN3 602-718; FN4 716-818; FN5 833-942; FN6 944-1044; P3 1390-1447. |
**[[2ed7]] – hDCC first fibronectin type III domain – human - NMR<BR /> | **[[2ed7]] – hDCC first fibronectin type III domain – human - NMR<BR /> | ||
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**[[2ede]] – hDCC sixth fibronectin type III domain - NMR<BR /> | **[[2ede]] – hDCC sixth fibronectin type III domain - NMR<BR /> | ||
**[[3au4]] – hDCC P3 motif + myosin-X <BR /> | **[[3au4]] – hDCC P3 motif + myosin-X <BR /> | ||
| + | **[[6bz3]] – hDCC P3 motif + focal adhesion kinase FAT domain <BR /> | ||
**[[4urt]] – hDCC fibronectin type V-VI domains + neutrin-1 <BR /> | **[[4urt]] – hDCC fibronectin type V-VI domains + neutrin-1 <BR /> | ||
| + | **[[5x83]] – hDCC fibronectin 4-6 domains <BR /> | ||
**[[4plo]] – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse<BR /> | **[[4plo]] – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse<BR /> | ||
**[[3pzd]] – mDCC P3 motif + myosin-X <BR /> | **[[3pzd]] – mDCC P3 motif + myosin-X <BR /> | ||
| + | **[[3laf]] – rDCC residues 39-421 - rat<BR /> | ||
| + | **[[5z5k]] – rDCC residues 39-421 + draxin peptide <BR /> | ||
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| + | *Netrin receptor UNC5 | ||
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| + | **[[8edc]] – `CeUNC5D Ig1+Ig2 domains 29-228 – ''Caenorhabditis elegans''<BR /> | ||
| + | **[[8edi]] – `CeUNC5D Ig1+Ig2 domains + heparin<BR /> | ||
*Netrin receptor UNC5A | *Netrin receptor UNC5A | ||
**[[4v2a]] – hUNC5A ectodomain <BR /> | **[[4v2a]] – hUNC5A ectodomain <BR /> | ||
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| + | *Netrin receptor UNC5B | ||
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| + | **[[6ool]] – mUNC5B ectodomain<BR /> | ||
| + | **[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | ||
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| + | *Netrin receptor UNC5D | ||
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| + | **[[4v2b]] – rUNC5D Ig1 domain <BR /> | ||
| + | **[[4v2c]] – rUNC5D Ig1 domain + FLRT2 LRR domain<BR /> | ||
| + | **[[7za1]], [[7za2]], [[7za3]] – rUNC5D residues 46-307 + glypican-3<BR /> | ||
| + | **[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | ||
*Netrin receptor UNC5H2 | *Netrin receptor UNC5H2 | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of netrin receptor
Updated on 13-July-2023
References
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Mehlen P, Llambi F. Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer. 2005 Jul 11;93(1):1-6. PMID:15956977 doi:http://dx.doi.org/10.1038/sj.bjc.6602656
