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5hs3

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==Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol==
==Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol==
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<StructureSection load='5hs3' size='340' side='right' caption='[[5hs3]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='5hs3' size='340' side='right'caption='[[5hs3]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hs3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HS3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hs3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HS3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KI3:3-AMINO-2-BENZOYL-4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL'>KI3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.103&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KI3:3-AMINO-2-BENZOYL-4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL'>KI3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hs3 OCA], [http://pdbe.org/5hs3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hs3 RCSB], [http://www.ebi.ac.uk/pdbsum/5hs3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hs3 OCA], [https://pdbe.org/5hs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hs3 RCSB], [https://www.ebi.ac.uk/pdbsum/5hs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hs3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
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[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hs3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hs3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thymidylate synthase]]
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[[Category: Homo sapiens]]
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[[Category: Almqvist, H]]
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[[Category: Large Structures]]
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[[Category: Artursson, P]]
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[[Category: Almqvist H]]
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[[Category: Axelsson, H]]
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[[Category: Artursson P]]
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[[Category: Chen, D]]
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[[Category: Axelsson H]]
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[[Category: Haraldsson, M]]
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[[Category: Chen D]]
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[[Category: Jafari, R]]
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[[Category: Haraldsson M]]
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[[Category: Larsson, A]]
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[[Category: Jafari R]]
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[[Category: Lundback, T]]
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[[Category: Larsson A]]
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[[Category: Mateus, A]]
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[[Category: Lundback T]]
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[[Category: Molina, D M]]
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[[Category: Mateus A]]
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[[Category: Nordlund, P]]
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[[Category: Molina DM]]
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[[Category: Nhibitor]]
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[[Category: Nordlund P]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol

PDB ID 5hs3

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