5ijc

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==The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex==
==The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex==
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<StructureSection load='5ijc' size='340' side='right' caption='[[5ijc]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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<StructureSection load='5ijc' size='340' side='right'caption='[[5ijc]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ijc]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hg4 5hg4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IJC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ijc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hg4 5hg4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=61S:TERT-BUTYL+(2R)-2-({4-AMINO-3-[2-(4-HYDROXYPHENYL)ETHYL]BENZOYL}AMINO)-4-PHENYLBUTANOATE'>61S</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ljb|5ljb]], [[5ljd|5ljd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=V2A:neoseptin+3'>V2A</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ijc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijc OCA], [http://pdbe.org/5ijc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ijc RCSB], [http://www.ebi.ac.uk/pdbsum/5ijc PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijc OCA], [https://pdbe.org/5ijc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijc RCSB], [https://www.ebi.ac.uk/pdbsum/5ijc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijc ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE]] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection.
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[https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE]] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref> [[http://www.uniprot.org/uniprot/LY96_MOUSE LY96_MOUSE]] Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity).
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[https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU] [https://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ijc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ijc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Berger, M]]
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[[Category: Eptatretus burgeri]]
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[[Category: Beutler, B]]
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[[Category: Large Structures]]
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[[Category: Boger, D L]]
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[[Category: Mus musculus]]
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[[Category: Choi, J H]]
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[[Category: Berger M]]
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[[Category: Huang, H]]
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[[Category: Beutler B]]
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[[Category: Jones, B T]]
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[[Category: Boger DL]]
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[[Category: Moresco, E M]]
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[[Category: Choi JH]]
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[[Category: Morin, M D]]
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[[Category: Huang H]]
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[[Category: Shi, H]]
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[[Category: Jones BT]]
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[[Category: Su, L]]
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[[Category: Moresco EM]]
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[[Category: Surakattula, M]]
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[[Category: Morin MD]]
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[[Category: Wang, K]]
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[[Category: Shi H]]
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[[Category: Wang, Y]]
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[[Category: Su L]]
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[[Category: Whitby, L R]]
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[[Category: Surakattula M]]
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[[Category: Zhan, X]]
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[[Category: Wang K]]
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[[Category: Zhang, H]]
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[[Category: Wang Y]]
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[[Category: Immune response]]
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[[Category: Whitby LR]]
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[[Category: Immune system]]
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[[Category: Zhan X]]
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[[Category: Protein complex]]
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[[Category: Zhang H]]
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[[Category: Small molecule agonist]]
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Current revision

The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex

PDB ID 5ijc

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