5f74

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==Crystal structure of ChREBP:14-3-3 complex bound with AMP==
==Crystal structure of ChREBP:14-3-3 complex bound with AMP==
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<StructureSection load='5f74' size='340' side='right' caption='[[5f74]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='5f74' size='340' side='right'caption='[[5f74]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5f74]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F74 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5f74]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F74 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f74 OCA], [http://pdbe.org/5f74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f74 RCSB], [http://www.ebi.ac.uk/pdbsum/5f74 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f74 OCA], [https://pdbe.org/5f74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f74 RCSB], [https://www.ebi.ac.uk/pdbsum/5f74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f74 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433B_MOUSE 1433B_MOUSE]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity). [[http://www.uniprot.org/uniprot/MLXPL_RAT MLXPL_RAT]] Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
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[https://www.uniprot.org/uniprot/1433B_MOUSE 1433B_MOUSE] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5f74" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5f74" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Jung, H]]
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[[Category: Large Structures]]
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[[Category: Uyeda, K]]
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[[Category: Mus musculus]]
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[[Category: 14-3-3]]
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[[Category: Rattus norvegicus]]
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[[Category: Allosteric]]
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[[Category: Jung H]]
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[[Category: Amp]]
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[[Category: Uyeda K]]
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[[Category: Chrebp]]
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[[Category: Transcription]]
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Current revision

Crystal structure of ChREBP:14-3-3 complex bound with AMP

PDB ID 5f74

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