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4caw

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==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==
==Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand==
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<StructureSection load='4caw' size='340' side='right' caption='[[4caw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4caw' size='340' side='right'caption='[[4caw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CAW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4caw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CAW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cav|4cav]], [[4cax|4cax]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=P3U:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>P3U</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [https://pdbe.org/4caw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [https://www.ebi.ac.uk/pdbsum/4caw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4caw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4caw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4caw OCA], [http://pdbe.org/4caw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4caw RCSB], [http://www.ebi.ac.uk/pdbsum/4caw PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
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[https://www.uniprot.org/uniprot/NMT_ASPFU NMT_ASPFU] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Aspergillus fumigatus]]
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[[Category: Aalten, D M.F Van]]
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[[Category: Large Structures]]
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[[Category: Blair, D E]]
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[[Category: Blair DE]]
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[[Category: Fang, W]]
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[[Category: Fang W]]
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[[Category: Gilbert, I H]]
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[[Category: Gilbert IH]]
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[[Category: Harrison, J]]
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[[Category: Harrison J]]
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[[Category: Lockhart, D E.A]]
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[[Category: Lockhart DEA]]
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[[Category: Raimi, O G]]
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[[Category: Raimi OG]]
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[[Category: Robinson, D A]]
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[[Category: Robinson DA]]
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[[Category: Ruda, G F]]
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[[Category: Ruda GF]]
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[[Category: Torrie, L S]]
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[[Category: Torrie LS]]
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[[Category: Wyatt, P G]]
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[[Category: Van Aalten DMF]]
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[[Category: Drug discovery]]
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[[Category: Wyatt PG]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand

PDB ID 4caw

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