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4zms

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==Structure of the full-length response regulator spr1814 in complex with a phosphate analogue and B3C==
==Structure of the full-length response regulator spr1814 in complex with a phosphate analogue and B3C==
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<StructureSection load='4zms' size='340' side='right' caption='[[4zms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4zms' size='340' side='right'caption='[[4zms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zms]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zms]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4QT:5-AMINO-2,4,6-TRIBROMOBENZENE-1,3-DIYL+DIHYDROPEROXIDE'>4QT</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zmr|4zmr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4QT:5-AMINO-2,4,6-TRIBROMOBENZENE-1,3-DIYL+DIHYDROPEROXIDE'>4QT</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zms OCA], [http://pdbe.org/4zms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zms RCSB], [http://www.ebi.ac.uk/pdbsum/4zms PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zms OCA], [https://pdbe.org/4zms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zms RCSB], [https://www.ebi.ac.uk/pdbsum/4zms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zms ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8DNC2_STRR6 Q8DNC2_STRR6]
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Spr1814 of Streptococcus pneumoniae is a response regulator (RR) that belongs to the NarL/FixJ subfamily and has a four-helix helix-turn-helix DNA-binding domain. Here, the X-ray crystal structure of the full-length spr1814 in complex with a phosphate analogue beryllium fluoride (BeF3(-)) was determined at 2.0 A. This allows for a structural comparison with the previously reported full-length unphosphorylated spr1814. The phosphorylation of conserved aspartic acid residue of N-terminal receiver domain triggers a structural perturbation at the alpha4-beta5-alpha5 interface, leading to the domain reorganization of spr1814, and this is achieved by a rotational change in the C-terminal DNA-binding domain.
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Structural characterization of the full-length response regulator spr1814 in complex with a phosphate analogue reveals a novel conformational plasticity of the linker region.,Park AK, Lee JH, Chi YM, Park H Biochem Biophys Res Commun. 2016 Apr 29;473(2):625-9. doi:, 10.1016/j.bbrc.2016.03.144. Epub 2016 Mar 30. PMID:27038544<ref>PMID:27038544</ref>
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==See Also==
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4zms" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chi, Y M]]
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[[Category: Large Structures]]
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[[Category: Park, A]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Dna binding protein]]
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[[Category: Chi YM]]
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[[Category: Response regulator]]
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[[Category: Park A]]

Current revision

Structure of the full-length response regulator spr1814 in complex with a phosphate analogue and B3C

PDB ID 4zms

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