5dkp

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==Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.==
==Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.==
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<StructureSection load='5dkp' size='340' side='right' caption='[[5dkp]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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<StructureSection load='5dkp' size='340' side='right'caption='[[5dkp]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dkp]] is a 56 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DKP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dkp]] is a 56 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_MC58 Neisseria meningitidis MC58] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.381&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=MP8:(4R)-4-METHYL-L-PROLINE'>MP8</scene>, <scene name='pdbligand=OTT:(2E,4E,6E)-OCTA-2,4,6-TRIENOIC+ACID'>OTT</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=MP8:(4R)-4-METHYL-L-PROLINE'>MP8</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OTT:(2E,4E,6E)-OCTA-2,4,6-TRIENOIC+ACID'>OTT</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkp OCA], [https://pdbe.org/5dkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dkp RCSB], [https://www.ebi.ac.uk/pdbsum/5dkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dkp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkp OCA], [http://pdbe.org/5dkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dkp RCSB], [http://www.ebi.ac.uk/pdbsum/5dkp PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLPP_NEIMB CLPP_NEIMB]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444]
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[https://www.uniprot.org/uniprot/CLPP_NEIMB CLPP_NEIMB] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dkp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dkp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Clp protease 3D structures|Clp protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Endopeptidase Clp]]
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[[Category: Large Structures]]
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[[Category: Batey, R A]]
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[[Category: Neisseria meningitidis MC58]]
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[[Category: Bryson, S]]
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[[Category: Synthetic construct]]
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[[Category: Eger, B T]]
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[[Category: Batey RA]]
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[[Category: Goodreid, J D]]
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[[Category: Bryson S]]
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[[Category: Gray-Owen, S D]]
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[[Category: Eger BT]]
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[[Category: Houry, W A]]
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[[Category: Goodreid JD]]
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[[Category: Janetzko, J]]
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[[Category: Gray-Owen SD]]
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[[Category: Leung, E]]
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[[Category: Houry WA]]
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[[Category: Maria, J P.Santa]]
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[[Category: Janetzko J]]
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[[Category: Pai, E F]]
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[[Category: Leung E]]
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[[Category: Walker, S]]
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[[Category: Pai EF]]
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[[Category: Wong, K]]
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[[Category: Santa Maria Jr JP]]
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[[Category: Agonist]]
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[[Category: Walker S]]
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[[Category: Antimicrobial]]
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[[Category: Wong K]]
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[[Category: Degradation]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-antibiotic complex]]
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Current revision

Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.

PDB ID 5dkp

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