5fn8

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==Crystal structure of rat CD45 extracellular region, domains d3-d4==
==Crystal structure of rat CD45 extracellular region, domains d3-d4==
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<StructureSection load='5fn8' size='340' side='right' caption='[[5fn8]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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<StructureSection load='5fn8' size='340' side='right'caption='[[5fn8]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fn8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fn8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FN8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fmv|5fmv]], [[5fn6|5fn6]], [[5fn7|5fn7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn8 OCA], [https://pdbe.org/5fn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fn8 RCSB], [https://www.ebi.ac.uk/pdbsum/5fn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn8 OCA], [http://pdbe.org/5fn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn8 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTPRC_RAT PTPRC_RAT]] Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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[https://www.uniprot.org/uniprot/PTPRC_RAT PTPRC_RAT] Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fn8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fn8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Aricescu, A R]]
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[[Category: Rattus norvegicus]]
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[[Category: Chang, V T]]
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[[Category: Aricescu AR]]
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[[Category: Coles, C H]]
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[[Category: Chang VT]]
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[[Category: Davis, S J]]
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[[Category: Coles CH]]
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[[Category: Fernandes, R A]]
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[[Category: Davis SJ]]
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[[Category: Ganzinger, K A]]
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[[Category: Fernandes RA]]
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[[Category: Gilbert, R J.C]]
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[[Category: Ganzinger KA]]
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[[Category: Harlos, K]]
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[[Category: Gilbert RJC]]
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[[Category: Huang, E]]
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[[Category: Harlos K]]
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[[Category: Jones, E Y]]
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[[Category: Huang E]]
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[[Category: Jonsson, P]]
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[[Category: Jones EY]]
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[[Category: Klenerman, D]]
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[[Category: Jonsson P]]
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[[Category: Lee, S F]]
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[[Category: Klenerman D]]
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[[Category: Lui, Y]]
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[[Category: Lee SF]]
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[[Category: McColl, J]]
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[[Category: Lui Y]]
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[[Category: Palayret, M]]
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[[Category: McColl J]]
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[[Category: Siebold, C]]
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[[Category: Palayret M]]
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[[Category: Cd45]]
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[[Category: Siebold C]]
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[[Category: Hydrolase]]
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[[Category: Ptprc]]
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[[Category: Receptor protein tyrosine phosphatase c]]
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Current revision

Crystal structure of rat CD45 extracellular region, domains d3-d4

PDB ID 5fn8

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