2n9h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Glucose as a nuclease mimic in DNA== | |
| + | <StructureSection load='2n9h' size='340' side='right'caption='[[2n9h]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9H FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JA:(2S)-3-[(6-DEOXY-BETA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYPROPYL+DIHYDROGEN+PHOSPHATE'>4JA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9h OCA], [https://pdbe.org/2n9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9h RCSB], [https://www.ebi.ac.uk/pdbsum/2n9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside-RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. | ||
| - | + | Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA.,Vengut-Climent E, Gomez-Pinto I, Lucas R, Penalver P, Avino A, Fonseca Guerra C, Bickelhaupt FM, Eritja R, Gonzalez C, Morales JC Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8643-7. doi: 10.1002/anie.201603510., Epub 2016 Jun 22. PMID:27328804<ref>PMID:27328804</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2n9h" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Gonzalez-Ibanez | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Avino A]] |
| - | [[Category: | + | [[Category: Bickelhaupt M]] |
| - | [[Category: | + | [[Category: Eritja R]] |
| - | [[Category: | + | [[Category: Fonseca-Guerra C]] |
| + | [[Category: Gomez-Pinto I]] | ||
| + | [[Category: Gonzalez-Ibanez C]] | ||
| + | [[Category: Lucas R]] | ||
| + | [[Category: Morales J]] | ||
| + | [[Category: Muro A]] | ||
| + | [[Category: Penalver P]] | ||
| + | [[Category: Vengut-Climent E]] | ||
Current revision
Glucose as a nuclease mimic in DNA
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