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5f2q

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Current revision (08:43, 12 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5f2q is ON HOLD until Paper Publication
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==C-type lectin from Bothrops jararacussu==
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<StructureSection load='5f2q' size='340' side='right'caption='[[5f2q]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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Authors: de Padua, R.A.P., Pinheiro, M.P., Sartim, M.A., Sampaio, S.V., Nonato, M.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f2q]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F2Q FirstGlance]. <br>
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Description: C-type lectin from Bothrops jararacussu
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Sartim, M.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f2q OCA], [https://pdbe.org/5f2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f2q RCSB], [https://www.ebi.ac.uk/pdbsum/5f2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f2q ProSAT]</span></td></tr>
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[[Category: Nonato, M.C]]
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</table>
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[[Category: Sampaio, S.V]]
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== Function ==
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[[Category: De Padua, R.A.P]]
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[https://www.uniprot.org/uniprot/LECG_BOTJR LECG_BOTJR] Galactose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids. Calcium-dependent lectin. Shows high hemagglutinating activity. When injected into mouse hind paws, (10-100 ug/paw) causes edema and increases vascular permeability. In anesthetized rats, decreases the blood pressure by approximately 15%, with a rapid return to the resting level (PubMed:16309723). Is an effective inhibitor of cell growth in some cancer cell lines, especially against renal and pancreatic cancer cell lines, human breast and ovarian carcinoma, glioblastoma and a bovine brain microvascular endothelial cell line (PubMed:10628348, PubMed:11478954).<ref>PMID:10628348</ref> <ref>PMID:11478954</ref> <ref>PMID:16309723</ref> <ref>PMID:11902666</ref>
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[[Category: Pinheiro, M.P]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bothrops jararacussu]]
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[[Category: Large Structures]]
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[[Category: Nonato MC]]
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[[Category: Pinheiro MP]]
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[[Category: Sampaio SV]]
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[[Category: Sartim MA]]
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[[Category: De Padua RAP]]

Current revision

C-type lectin from Bothrops jararacussu

PDB ID 5f2q

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