This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5fxu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:30, 26 July 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5fxu is ON HOLD until Paper Publication
+
==Crystal Structure of Puumala virus Gn glycoprotein ectodomain==
 +
<StructureSection load='5fxu' size='340' side='right'caption='[[5fxu]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5fxu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Puumala_orthohantavirus Puumala orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FXU FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxu OCA], [https://pdbe.org/5fxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fxu RCSB], [https://www.ebi.ac.uk/pdbsum/5fxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fxu ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9WJ31_9VIRU Q9WJ31_9VIRU]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion. The accuracy of the fitting was corroborated by epitope mapping and genetic analysis of available PUUV sequences. Interestingly, Gn exhibits greater non-synonymous sequence diversity than the less accessible Gc, supporting a role of the host humoral immune response in exerting selective pressure on the virus surface. The fold of PUUV Gn is likely to be widely conserved across hantaviruses.
-
Authors: Li, S., Rissanen, I., Zeltina, A., Hepojoki, J., Raghwani, J., Harlos, K., Pybus, O.G., Huiskonen, J.T., Bowden, T.A.
+
A Molecular-Level Account of the Antigenic Hantaviral Surface.,Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA Cell Rep. 2016 May 3;15(5):959-67. doi: 10.1016/j.celrep.2016.03.082. Epub 2016, Apr 21. PMID:27117403<ref>PMID:27117403</ref>
-
Description: Crystal Structure of Puumala virus Gn glycoprotein ectodomain
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Li, S]]
+
<div class="pdbe-citations 5fxu" style="background-color:#fffaf0;"></div>
-
[[Category: Raghwani, J]]
+
== References ==
-
[[Category: Pybus, O.G]]
+
<references/>
-
[[Category: Zeltina, A]]
+
__TOC__
-
[[Category: Rissanen, I]]
+
</StructureSection>
-
[[Category: Bowden, T.A]]
+
[[Category: Large Structures]]
-
[[Category: Huiskonen, J.T]]
+
[[Category: Puumala orthohantavirus]]
-
[[Category: Harlos, K]]
+
[[Category: Bowden TA]]
-
[[Category: Hepojoki, J]]
+
[[Category: Harlos K]]
 +
[[Category: Hepojoki J]]
 +
[[Category: Huiskonen JT]]
 +
[[Category: Li S]]
 +
[[Category: Pybus OG]]
 +
[[Category: Raghwani J]]
 +
[[Category: Rissanen I]]
 +
[[Category: Zeltina A]]

Current revision

Crystal Structure of Puumala virus Gn glycoprotein ectodomain

PDB ID 5fxu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fxu"
Personal tools