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5fyn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5fyn is ON HOLD until Paper Publication Authors: Li, S., Rissanen, I., Zeltina, A., Hepojoki, J., Raghwani, J., Harlos, K., Pybus, O.G., Huiskonen, ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Sub-tomogram averaging of Tula virus glycoprotein spike== | |
| + | <SX load='5fyn' size='340' side='right' viewer='molstar' caption='[[5fyn]], [[Resolution|resolution]] 15.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5fyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Puumala_orthohantavirus Puumala orthohantavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FYN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyn OCA], [https://pdbe.org/5fyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fyn RCSB], [https://www.ebi.ac.uk/pdbsum/5fyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fyn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9WJ31_9VIRU Q9WJ31_9VIRU] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion. The accuracy of the fitting was corroborated by epitope mapping and genetic analysis of available PUUV sequences. Interestingly, Gn exhibits greater non-synonymous sequence diversity than the less accessible Gc, supporting a role of the host humoral immune response in exerting selective pressure on the virus surface. The fold of PUUV Gn is likely to be widely conserved across hantaviruses. | ||
| - | + | A Molecular-Level Account of the Antigenic Hantaviral Surface.,Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA Cell Rep. 2016 May 3;15(5):959-67. doi: 10.1016/j.celrep.2016.03.082. Epub 2016, Apr 21. PMID:27117403<ref>PMID:27117403</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5fyn" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: | + | *[[Sandbox 3001|Sandbox 3001]] |
| - | [[Category: | + | *[[Spike protein|Spike protein]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </SX> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Puumala orthohantavirus]] | ||
| + | [[Category: Bowden TA]] | ||
| + | [[Category: Harlos K]] | ||
| + | [[Category: Hepojoki J]] | ||
| + | [[Category: Huiskonen JT]] | ||
| + | [[Category: Li S]] | ||
| + | [[Category: Pybus OG]] | ||
| + | [[Category: Raghwani J]] | ||
| + | [[Category: Rissanen I]] | ||
| + | [[Category: Zeltina A]] | ||
Current revision
Sub-tomogram averaging of Tula virus glycoprotein spike
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