5fzh

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'''Unreleased structure'''
 
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The entry 5fzh is ON HOLD
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==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 4,5-dihydronaphtho(1,2-b)thiophene-2- carboxylicacid (N11181a) (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)==
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<StructureSection load='5fzh' size='340' side='right'caption='[[5fzh]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fzh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TI:(3R)-5-FLUORO-3-HYDROXY-1,3-DIHYDRO-2H-INDOL-2-ONE'>0TI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzh OCA], [https://pdbe.org/5fzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzh RCSB], [https://www.ebi.ac.uk/pdbsum/5fzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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Authors: Nowak, R., Krojer, T., Johansson, C., Kupinska, K., Szykowska, A., Pearce, N., Talon, R., Collins, P., Gileadi, C., Strain-Damerell, C., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Von Delft, F., Brennan, P.E., Oppermann, U.
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==See Also==
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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Description: Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 4,5-dihydronaphtho(1,2-b)thiophene-2-carboxylicacid (N11181a) (ligand modelled based on PANDDA event map, SGC -Diamond I04-1 fragment screening)
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Nowak, R]]
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<references/>
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[[Category: Burgess-Brown, N.A]]
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__TOC__
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[[Category: Krojer, T]]
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</StructureSection>
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[[Category: Bountra, C]]
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[[Category: Homo sapiens]]
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[[Category: Kupinska, K]]
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[[Category: Large Structures]]
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[[Category: Collins, P]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Bountra C]]
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[[Category: Gileadi, C]]
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[[Category: Brennan PE]]
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[[Category: Oppermann, U]]
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[[Category: Burgess-Brown NA]]
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[[Category: Szykowska, A]]
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[[Category: Collins P]]
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[[Category: Von Delft, F]]
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[[Category: Edwards AM]]
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[[Category: Pearce, N]]
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[[Category: Gileadi C]]
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[[Category: Edwards, A.M]]
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[[Category: Johansson C]]
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[[Category: Talon, R]]
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[[Category: Krojer T]]
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[[Category: Johansson, C]]
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[[Category: Kupinska K]]
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[[Category: Brennan, P.E]]
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[[Category: Nowak R]]
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[[Category: Strain-Damerell, C]]
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[[Category: Oppermann U]]
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[[Category: Pearce N]]
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[[Category: Strain-Damerell C]]
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[[Category: Szykowska A]]
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[[Category: Talon R]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 4,5-dihydronaphtho(1,2-b)thiophene-2- carboxylicacid (N11181a) (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)

PDB ID 5fzh

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