1hsk

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[[Image:1hsk.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF S. AUREUS MURB==
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|PDB= 1hsk |SIZE=350|CAPTION= <scene name='initialview01'>1hsk</scene>, resolution 2.30&Aring;
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<StructureSection load='1hsk' size='340' side='right'caption='[[1hsk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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<table><tr><td colspan='2'>[[1hsk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HSK FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramate_dehydrogenase UDP-N-acetylmuramate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.158 1.1.1.158] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsk OCA], [https://pdbe.org/1hsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hsk RCSB], [https://www.ebi.ac.uk/pdbsum/1hsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hsk ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsk OCA], [http://www.ebi.ac.uk/pdbsum/1hsk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hsk RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MURB_STAAU MURB_STAAU]
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== Evolutionary Conservation ==
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'''CRYSTAL STRUCTURE OF S. AUREUS MURB'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/1hsk_consurf.spt"</scriptWhenChecked>
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The X-ray crystal structure of the substrate free form of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) has been solved to 2.3 A resolution with an R-factor of 20.3% and a free R-factor of 22.3%. While the overall fold of the S. aureus enzyme is similar to that of the homologous Escherichia coli MurB X-ray crystal structure, notable distinctions between the S. aureus and E. coli MurB protein structures occur in residues involved in substrate binding. Analysis of available MurB sequences from other bacteria suggest that the S. aureus MurB structure is representative of a distinct structural class of UDP-N-acetylenolpyruvylglucosamine reductases including Bacillus subtilis and Helicobacter pylori that are characterized by a modified mechanism for substrate binding.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1HSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSK OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hsk ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB)., Benson TE, Harris MS, Choi GH, Cialdella JI, Herberg JT, Martin JP Jr, Baldwin ET, Biochemistry. 2001 Feb 27;40(8):2340-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11327854 11327854]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: UDP-N-acetylmuramate dehydrogenase]]
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[[Category: Baldwin ET]]
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[[Category: Baldwin, E T.]]
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[[Category: Benson TE]]
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[[Category: Benson, T E.]]
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[[Category: Choi GH]]
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[[Category: Choi, G H.]]
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[[Category: Cialdella JI]]
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[[Category: Cialdella, J I.]]
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[[Category: Harris MS]]
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[[Category: Harris, M S.]]
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[[Category: Herberg JT]]
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[[Category: Herberg, J T.]]
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[[Category: Martin Jr JP]]
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[[Category: Jr., J P.Martin.]]
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[[Category: cell division]]
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[[Category: cell wall]]
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[[Category: fad]]
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[[Category: flavoprotein]]
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[[Category: nadp]]
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[[Category: oxidoreductase]]
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[[Category: peptidoglycan synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:09:54 2008''
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Current revision

CRYSTAL STRUCTURE OF S. AUREUS MURB

PDB ID 1hsk

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