1hv7

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[[Image:1hv7.jpg|left|200px]]
 
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{{Structure
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==PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A==
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|PDB= 1hv7 |SIZE=350|CAPTION= <scene name='initialview01'>1hv7</scene>, resolution 1.7&Aring;
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<StructureSection load='1hv7' size='340' side='right'caption='[[1hv7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=616:N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE'>616</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1hv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV7 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=616:N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE'>616</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv7 OCA], [https://pdbe.org/1hv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv7 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv7 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv7 OCA], [http://www.ebi.ac.uk/pdbsum/1hv7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hv7 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/1hv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hv7 ConSurf].
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<div style="clear:both"></div>
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'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A'''
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==See Also==
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*[[Elastase 3D structures|Elastase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
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[[Category: Large Structures]]
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==About this Structure==
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1HV7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV7 OCA].
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==Reference==
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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate., Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H, Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11294386 11294386]
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[[Category: Pancreatic elastase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Singh, O M.]]
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[[Category: Singh OM]]
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[[Category: Skarzynski, T.]]
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[[Category: Skarzynski T]]
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[[Category: serine protease-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:54 2008''
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Current revision

PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A

PDB ID 1hv7

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