5ixb
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5ixb is ON HOLD until Paper Publication Authors: Yip, K.T., Gasper, R., Zhong, X.Y., Seibel, N., Puetz, S., Autzen, J., Scherkenbeck, J., Hofmann, E...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human Melanoma Inhibitory Activity (MIA) Protein in complex with Pyrimidin-2-amine== | |
| + | <StructureSection load='5ixb' size='340' side='right'caption='[[5ixb]], [[Resolution|resolution]] 1.39Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ixb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IXB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=LGA:PYRIMIDIN-2-AMINE'>LGA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixb OCA], [https://pdbe.org/5ixb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ixb RCSB], [https://www.ebi.ac.uk/pdbsum/5ixb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Melanoma inhibitory activity (MIA), an extracellular protein highly expressed by malignant melanoma cells, plays an important functional role in melanoma development, progression, and metastasis. After its secretion, MIA directly interacts with extracellular matrix proteins, such as fibronectin (FN). By this mechanism, MIA actively facilitates focal cell detachment from surrounding structures and strongly promotes tumour cell invasion and migration. Hence, the molecular understanding of MIA's function provides a promising target for the development of new strategies in malignant melanoma therapy. Here, we describe for the first time the discovery of small molecules that are able to disrupt the MIA-FN complex by selectively binding to a new druggable pocket, which we could identify on MIA by structural analysis and fragment-based screening. Our findings may inspire novel drug discovery efforts aiming at a therapeutically effective treatment of melanoma by targeting MIA. | ||
| - | + | Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma.,Yip KT, Zhong XY, Seibel N, Putz S, Autzen J, Gasper R, Hofmann E, Scherkenbeck J, Stoll R Sci Rep. 2016 May 6;6:25119. doi: 10.1038/srep25119. PMID:27151361<ref>PMID:27151361</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5ixb" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Stoll | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Autzen J]] |
| - | [[Category: | + | [[Category: Gasper R]] |
| + | [[Category: Hofmann E]] | ||
| + | [[Category: Puetz S]] | ||
| + | [[Category: Scherkenbeck J]] | ||
| + | [[Category: Seibel N]] | ||
| + | [[Category: Stoll R]] | ||
| + | [[Category: Yip KT]] | ||
| + | [[Category: Zhong XY]] | ||
Current revision
Structure of human Melanoma Inhibitory Activity (MIA) Protein in complex with Pyrimidin-2-amine
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Categories: Homo sapiens | Large Structures | Autzen J | Gasper R | Hofmann E | Puetz S | Scherkenbeck J | Seibel N | Stoll R | Yip KT | Zhong XY
