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5j3r

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'''Unreleased structure'''
 
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The entry 5j3r is ON HOLD until Paper Publication
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==Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster==
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<StructureSection load='5j3r' size='340' side='right'caption='[[5j3r]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5j3r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J3R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j3r OCA], [https://pdbe.org/5j3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j3r RCSB], [https://www.ebi.ac.uk/pdbsum/5j3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j3r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLRX6_YEAST GLRX6_YEAST]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutaredoxins (Grxs) constitute a superfamily of proteins that perform diverse biological functions. The Saccharomyces cerevisiae glutaredoxin Grx6 not only serves as a glutathione (GSH)-dependent oxidoreductase and as a GSH transferase, but also as an essential [2Fe-2S]-binding protein. Here, the dimeric structure of the C-terminal domain of Grx6 (holo Grx6C), bridged by one [2Fe-2S] cluster coordinated by the active-site Cys136 and two external GSH molecules, is reported. Structural comparison combined with multiple-sequence alignment demonstrated that holo Grx6C is similar to the [2Fe-2S] cluster-incorporated dithiol Grxs, which share a highly conserved [2Fe-2S] cluster-binding pattern and dimeric conformation that is distinct from the previously identified [2Fe-2S] cluster-ligated monothiol Grxs.
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Authors: Abdalla, M., Dai, Y.-N., Chi, C.-B., Cheng, W., Cao, D.-D., Zhou, K., Ali, W., Chen, Y., Zhou, C.-Z.
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Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster.,Abdalla M, Dai YN, Chi CB, Cheng W, Cao DD, Zhou K, Ali W, Chen Y, Zhou CZ Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):732-737. Epub 2016, Sep 22. PMID:27710937<ref>PMID:27710937</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Dai, Y.-N]]
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<div class="pdbe-citations 5j3r" style="background-color:#fffaf0;"></div>
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[[Category: Chen, Y]]
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== References ==
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[[Category: Chi, C.-B]]
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<references/>
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[[Category: Zhou, K]]
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__TOC__
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[[Category: Zhou, C.-Z]]
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</StructureSection>
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[[Category: Abdalla, M]]
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[[Category: Large Structures]]
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[[Category: Ali, W]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Cao, D.-D]]
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[[Category: Abdalla M]]
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[[Category: Cheng, W]]
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[[Category: Ali W]]
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[[Category: Cao D-D]]
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[[Category: Chen Y]]
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[[Category: Cheng W]]
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[[Category: Chi C-B]]
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[[Category: Dai Y-N]]
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[[Category: Zhou C-Z]]
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[[Category: Zhou K]]

Current revision

Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster

PDB ID 5j3r

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