1i1r

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[[Image:1i1r.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX==
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|PDB= 1i1r |SIZE=350|CAPTION= <scene name='initialview01'>1i1r</scene>, resolution 2.4&Aring;
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<StructureSection load='1i1r' size='340' side='right'caption='[[1i1r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1i1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1R FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1r OCA], [https://pdbe.org/1i1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1r RCSB], [https://www.ebi.ac.uk/pdbsum/1i1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1r ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1r OCA], [http://www.ebi.ac.uk/pdbsum/1i1r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i1r RCSB]</span>
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[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i1r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i1r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma-associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130. In the 2.4 angstrom crystal structure of the extracellular signaling assembly between viral IL-6 and human gp130, two complexes are cross-linked into a tetramer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-6, which is necessary for receptor activation. Unlike human IL-6 (which uses many hydrophilic residues), the viral cytokine largely uses hydrophobic amino acids to contact gp130, which enhances the complementarity of the viral IL-6-gp130 binding interfaces. The cross-reactivity of gp130 is apparently due to a chemical plasticity evident in the amphipathic gp130 cytokine-binding sites.
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'''CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX'''
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Structure of an extracellular gp130 cytokine receptor signaling complex.,Chow D, He X, Snow AL, Rose-John S, Garcia KC Science. 2001 Mar 16;291(5511):2150-5. PMID:11251120<ref>PMID:11251120</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1i1r" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma-associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130. In the 2.4 angstrom crystal structure of the extracellular signaling assembly between viral IL-6 and human gp130, two complexes are cross-linked into a tetramer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-6, which is necessary for receptor activation. Unlike human IL-6 (which uses many hydrophilic residues), the viral cytokine largely uses hydrophobic amino acids to contact gp130, which enhances the complementarity of the viral IL-6-gp130 binding interfaces. The cross-reactivity of gp130 is apparently due to a chemical plasticity evident in the amphipathic gp130 cytokine-binding sites.
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1I1R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1R OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Structure of an extracellular gp130 cytokine receptor signaling complex., Chow D, He X, Snow AL, Rose-John S, Garcia KC, Science. 2001 Mar 16;291(5511):2150-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11251120 11251120]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human herpesvirus 8]]
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[[Category: Human gammaherpesvirus 8]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Chow, D.]]
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[[Category: Chow D]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: He, X.]]
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[[Category: He X]]
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[[Category: Rose-John, S.]]
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[[Category: Rose-John S]]
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[[Category: Snow, A L.]]
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[[Category: Snow AL]]
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[[Category: crystal structure]]
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[[Category: cytokine/receptor complex]]
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[[Category: gp130]]
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[[Category: viral il-6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:22 2008''
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Current revision

CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX

PDB ID 1i1r

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