5d4k

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==Crystal structure of the human polymeric Ig receptor (pIgR) ectodomain==
==Crystal structure of the human polymeric Ig receptor (pIgR) ectodomain==
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<StructureSection load='5d4k' size='340' side='right' caption='[[5d4k]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5d4k' size='340' side='right'caption='[[5d4k]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5d4k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D4K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5d4k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D4K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.599&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f1s|5f1s]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d4k OCA], [http://pdbe.org/5d4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d4k RCSB], [http://www.ebi.ac.uk/pdbsum/5d4k PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d4k OCA], [https://pdbe.org/5d4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d4k RCSB], [https://www.ebi.ac.uk/pdbsum/5d4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d4k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
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[https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bjorkman, P J]]
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[[Category: Homo sapiens]]
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[[Category: Stadtmueller, B M]]
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[[Category: Large Structures]]
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[[Category: Immune system]]
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[[Category: Bjorkman PJ]]
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[[Category: Mucosal immunity]]
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[[Category: Stadtmueller BM]]
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[[Category: Polymeric ig-binding protein]]
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[[Category: Secretory component]]
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Current revision

Crystal structure of the human polymeric Ig receptor (pIgR) ectodomain

PDB ID 5d4k

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