5fua

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==Cryo-EM of BK polyomavirus==
==Cryo-EM of BK polyomavirus==
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<StructureSection load='5fua' size='340' side='right' caption='[[5fua]], [[Resolution|resolution]] 7.60&Aring;' scene=''>
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<SX load='5fua' size='340' side='right' viewer='molstar' caption='[[5fua]], [[Resolution|resolution]] 7.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fua]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bk_polyomavirus Bk polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fua]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_polyomavirus_1 Human polyomavirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FUA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fua OCA], [http://pdbe.org/5fua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fua RCSB], [http://www.ebi.ac.uk/pdbsum/5fua PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fua OCA], [https://pdbe.org/5fua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fua RCSB], [https://www.ebi.ac.uk/pdbsum/5fua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fua ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VP1_POVBK VP1_POVBK]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with gangliosides GT1b and GD1b containing terminal alpha(2-8)-linked sialic acids on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA (By similarity).<ref>PMID:15479799</ref> <ref>PMID:16415013</ref>
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[https://www.uniprot.org/uniprot/VP1_POVBK VP1_POVBK] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with gangliosides GT1b and GD1b containing terminal alpha(2-8)-linked sialic acids on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA (By similarity).<ref>PMID:15479799</ref> <ref>PMID:16415013</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fua" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fua" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Bk polyomavirus]]
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[[Category: Human polyomavirus 1]]
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[[Category: Hurdiss, D L]]
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[[Category: Large Structures]]
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[[Category: Macdonald, A]]
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[[Category: Hurdiss DL]]
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[[Category: Morgan, E L]]
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[[Category: Macdonald A]]
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[[Category: Panou, M M]]
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[[Category: Morgan EL]]
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[[Category: Prescott, E L]]
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[[Category: Panou MM]]
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[[Category: Ranson, N A]]
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[[Category: Prescott EL]]
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[[Category: Thompson, R F]]
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[[Category: Ranson NA]]
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[[Category: Bk]]
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[[Category: Thompson RF]]
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[[Category: Bkpyv]]
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[[Category: Polyomavirus]]
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[[Category: Virus]]
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Cryo-EM of BK polyomavirus

5fua, resolution 7.60Å

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