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4uis

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==The cryoEM structure of human gamma-Secretase complex==
==The cryoEM structure of human gamma-Secretase complex==
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<StructureSection load='4uis' size='340' side='right' caption='[[4uis]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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<SX load='4uis' size='340' side='right' viewer='molstar' caption='[[4uis]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uis]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UIS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uis]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UIS FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uis OCA], [https://pdbe.org/4uis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uis RCSB], [https://www.ebi.ac.uk/pdbsum/4uis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uis ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uis OCA], [http://pdbe.org/4uis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uis RCSB], [http://www.ebi.ac.uk/pdbsum/4uis PDBsum]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4uis" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4uis" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Gamma secretase|Gamma secretase]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Lysozyme]]
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[[Category: Homo sapiens]]
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[[Category: Li, X]]
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[[Category: Large Structures]]
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[[Category: Shi, Y]]
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[[Category: Li X]]
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[[Category: Sun, L]]
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[[Category: Shi Y]]
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[[Category: Wu, S]]
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[[Category: Sun L]]
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[[Category: Xie, T]]
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[[Category: Wu S]]
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[[Category: Yan, C]]
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[[Category: Xie T]]
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[[Category: Yang, G]]
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[[Category: Yan C]]
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[[Category: Zhao, L]]
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[[Category: Yang G]]
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[[Category: Zhao, Y]]
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[[Category: Zhao L]]
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[[Category: Zhou, R]]
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[[Category: Zhao Y]]
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[[Category: Zhou, X]]
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[[Category: Zhou R]]
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[[Category: Gamma-secretase]]
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[[Category: Zhou X]]
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[[Category: Hydrolase]]
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Current revision

The cryoEM structure of human gamma-Secretase complex

4uis, resolution 4.40Å

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