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4ywz

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==Crystal structure of the extracellular receptor domain of the essential sensor kinase WalK from Staphylococcus aureus==
==Crystal structure of the extracellular receptor domain of the essential sensor kinase WalK from Staphylococcus aureus==
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<StructureSection load='4ywz' size='340' side='right' caption='[[4ywz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4ywz' size='340' side='right'caption='[[4ywz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ywz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ywz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YWZ FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ywz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywz OCA], [https://pdbe.org/4ywz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ywz RCSB], [https://www.ebi.ac.uk/pdbsum/4ywz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ywz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywz OCA], [http://pdbe.org/4ywz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ywz RCSB], [http://www.ebi.ac.uk/pdbsum/4ywz PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/WALK_STAAB WALK_STAAB]] Member of the two-component regulatory system WalK/WalR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to WalR (By similarity).
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[https://www.uniprot.org/uniprot/WALK_STAAE WALK_STAAE] Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.[UniProtKB:Q9RDT3]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histidine kinase]]
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[[Category: Large Structures]]
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[[Category: He, C]]
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[[Category: Ji, Q]]
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[[Category: Wawrzak, Z]]
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[[Category: Essential]]
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[[Category: Extracellular receptor]]
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[[Category: Kinase]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Transferase]]
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[[Category: He C]]
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[[Category: Ji Q]]
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[[Category: Wawrzak Z]]

Current revision

Crystal structure of the extracellular receptor domain of the essential sensor kinase WalK from Staphylococcus aureus

PDB ID 4ywz

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