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4yjg

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==Crystal structure of DAAO(Y228L/R283G) variant (R-3-amino 1-phenylbutane binding form)==
==Crystal structure of DAAO(Y228L/R283G) variant (R-3-amino 1-phenylbutane binding form)==
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<StructureSection load='4yjg' size='340' side='right' caption='[[4yjg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4yjg' size='340' side='right'caption='[[4yjg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yjg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YJG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yjg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YJG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4DD:(2R)-4-PHENYLBUTAN-2-AMINE'>4DD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yjh|4yjh]], [[4yjf|4yjf]], [[4yjd|4yjd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DD:(2R)-4-PHENYLBUTAN-2-AMINE'>4DD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yjg OCA], [https://pdbe.org/4yjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yjg RCSB], [https://www.ebi.ac.uk/pdbsum/4yjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yjg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yjg OCA], [http://pdbe.org/4yjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yjg RCSB], [http://www.ebi.ac.uk/pdbsum/4yjg PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
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[https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
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==See Also==
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: D-amino-acid oxidase]]
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[[Category: Large Structures]]
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[[Category: Asano, Y]]
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[[Category: Sus scrofa]]
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[[Category: Ishitsubo, E]]
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[[Category: Asano Y]]
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[[Category: Kawahara, N]]
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[[Category: Ishitsubo E]]
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[[Category: Nakano, S]]
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[[Category: Kawahara N]]
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[[Category: Tokiwa, H]]
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[[Category: Nakano S]]
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[[Category: Yasukawa, K]]
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[[Category: Tokiwa H]]
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[[Category: Amine oxidase]]
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[[Category: Yasukawa K]]
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[[Category: Oxidoreductase]]
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[[Category: S-methylbenzylamine binding form]]
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[[Category: Variant of d-amino acid oxidase]]
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Current revision

Crystal structure of DAAO(Y228L/R283G) variant (R-3-amino 1-phenylbutane binding form)

PDB ID 4yjg

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