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4zvs

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==Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor.==
==Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor.==
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<StructureSection load='4zvs' size='340' side='right' caption='[[4zvs]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4zvs' size='340' side='right'caption='[[4zvs]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zvs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZVS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zvs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZVS FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zvt|4zvt]], [[4zvu|4zvu]], [[4zvq|4zvq]], [[4zvp|4zvp]], [[4zvo|4zvo]], [[4zvr|4zvr]], [[1f1j|1f1j]], [[3edr|3edr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvs OCA], [https://pdbe.org/4zvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zvs RCSB], [https://www.ebi.ac.uk/pdbsum/4zvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvs OCA], [http://pdbe.org/4zvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zvs RCSB], [http://www.ebi.ac.uk/pdbsum/4zvs PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zvs" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zvs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-7]]
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[[Category: Homo sapiens]]
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[[Category: Hardy, J A]]
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[[Category: Large Structures]]
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[[Category: Hill, M E]]
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[[Category: Synthetic construct]]
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[[Category: MacPherson, D J]]
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[[Category: Hardy JA]]
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[[Category: Designed active site specificity]]
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[[Category: Hill ME]]
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[[Category: Directed evolution]]
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[[Category: MacPherson DJ]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Peptide inhibitor]]
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[[Category: Protease]]
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Current revision

Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor.

PDB ID 4zvs

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