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5j7e
From Proteopedia
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==hEAG PAS domain== | ==hEAG PAS domain== | ||
| - | <StructureSection load='5j7e' size='340' side='right' caption='[[5j7e]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [https://pdbe.org/5j7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [https://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Juan S]] |
| - | [[Category: | + | [[Category: Xiaohong Q]] |
| - | [[Category: | + | [[Category: Xue T]] |
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| - | + | ||
Current revision
hEAG PAS domain
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