5ep6

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'''Unreleased structure'''
 
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The entry 5ep6 is ON HOLD until Paper Publication
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==The crystal structure of NAP1 in complex with TBK1==
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<StructureSection load='5ep6' size='340' side='right'caption='[[5ep6]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ep6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EP6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.451&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ep6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ep6 OCA], [https://pdbe.org/5ep6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ep6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ep6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ep6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AZI2_HUMAN AZI2_HUMAN] Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.<ref>PMID:14560022</ref> <ref>PMID:15611223</ref> <ref>PMID:21931631</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li F]]
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[[Category: Liu J]]
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[[Category: Pan L]]
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[[Category: Xie X]]

Current revision

The crystal structure of NAP1 in complex with TBK1

PDB ID 5ep6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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