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5hob
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==p73 homo-tetramerization domain mutant I== | |
| + | <StructureSection load='5hob' size='340' side='right'caption='[[5hob]], [[Resolution|resolution]] 1.22Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5hob]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HOB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.220013Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hob OCA], [https://pdbe.org/5hob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hob RCSB], [https://www.ebi.ac.uk/pdbsum/5hob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hob ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[P73|P73]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Coutandin D]] | ||
| + | [[Category: Dotsch V]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Mathea S]] | ||
| + | [[Category: Salah E]] | ||
Current revision
p73 homo-tetramerization domain mutant I
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Categories: Homo sapiens | Large Structures | Coutandin D | Dotsch V | Knapp S | Krojer T | Mathea S | Salah E
