|
|
| (11 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| - | [[Image:1ih3.gif|left|200px]] | |
| | | | |
| - | {{Structure
| + | ==Multi-conformation crystal structure of GGm5CGm5CC== |
| - | |PDB= 1ih3 |SIZE=350|CAPTION= <scene name='initialview01'>1ih3</scene>, resolution 2.4Å
| + | <StructureSection load='1ih3' size='340' side='right'caption='[[1ih3]], [[Resolution|resolution]] 2.40Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=5CM:5-METHYL-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene> | + | <table><tr><td colspan='2'>[[1ih3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IH3 FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | |GENE=
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr> |
| - | |DOMAIN=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ih3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih3 OCA], [https://pdbe.org/1ih3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ih3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ih3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ih3 ProSAT]</span></td></tr> |
| - | |RELATEDENTRY=[[1ih1|1IH1]], [[1ih2|1IH2]], [[1ih4|1IH4]], [[1ih6|1IH6]]
| + | </table> |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ih3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih3 OCA], [http://www.ebi.ac.uk/pdbsum/1ih3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ih3 RCSB]</span>
| + | __TOC__ |
| - | }}
| + | </StructureSection> |
| - | | + | [[Category: Large Structures]] |
| - | '''Multi-conformation crystal structure of GGm5CGm5CC'''
| + | [[Category: Henderson K]] |
| - | | + | [[Category: Ho PS]] |
| - | | + | [[Category: Vargason JM]] |
| - | ==Overview==
| + | |
| - | The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1IH3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH3 OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969]
| + | |
| - | [[Category: Protein complex]] | + | |
| - | [[Category: Henderson, K.]] | + | |
| - | [[Category: Ho, P S.]] | + | |
| - | [[Category: Vargason, J M.]] | + | |
| - | [[Category: b to a dna transition]]
| + | |
| - | [[Category: dna transition]]
| + | |
| - | [[Category: structural transition]]
| + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:40 2008''
| + | |
