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5j12

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'''Unreleased structure'''
 
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The entry 5j12 is ON HOLD until Paper Publication
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==Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha==
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<StructureSection load='5j12' size='340' side='right'caption='[[5j12]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [https://pdbe.org/5j12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [https://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref>
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Authors:
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==See Also==
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Savvides SN]]
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[[Category: Verstraete K]]

Current revision

Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha

PDB ID 5j12

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OCA

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