1ijl

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[[Image:1ijl.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus==
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|PDB= 1ijl |SIZE=350|CAPTION= <scene name='initialview01'>1ijl</scene>, resolution 2.6&Aring;
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<StructureSection load='1ijl' size='340' side='right'caption='[[1ijl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1ijl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJL FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ijl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijl OCA], [https://pdbe.org/1ijl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ijl RCSB], [https://www.ebi.ac.uk/pdbsum/1ijl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ijl ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1psj|1PSJ]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ijl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijl OCA], [http://www.ebi.ac.uk/pdbsum/1ijl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ijl RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PA2A_DEIAC PA2A_DEIAC] Snake venom phospholipase A2 (PLA2) that inhibits ADP-induced platelet aggregation. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:8931260</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/1ijl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ijl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An acidic phospholipase A(2) was purified from Deinagkistrodon acutus (Agkistrodon acutus) which displays an inhibitory effect on platelet aggregation. The three-dimensional structure of the enzyme was determined by molecular replacement at 2.6 A resolution with a crystallographic R factor of 18.40% (R(free) = 22.50%) and reasonable stereochemistry. Two molecules in the asymmetric unit form a dimer and the dimer formation accompanies a significant conformational adaptation of segment 14-23, a constituent of the 'interface recognition site' (IRS). This probably reflects the inherent structural flexibility of the IRS. The possible expansion of the site for inhibiting platelet aggregation as proposed previously [Wang et al. (1996), J. Mol. Biol. 255, 669-676] is discussed.
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'''Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus'''
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Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus.,Gu L, Zhang H, Song S, Zhou Y, Lin Z Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):104-10. Epub 2001, Dec 21. PMID:11752784<ref>PMID:11752784</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ijl" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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An acidic phospholipase A(2) was purified from Deinagkistrodon acutus (Agkistrodon acutus) which displays an inhibitory effect on platelet aggregation. The three-dimensional structure of the enzyme was determined by molecular replacement at 2.6 A resolution with a crystallographic R factor of 18.40% (R(free) = 22.50%) and reasonable stereochemistry. Two molecules in the asymmetric unit form a dimer and the dimer formation accompanies a significant conformational adaptation of segment 14-23, a constituent of the 'interface recognition site' (IRS). This probably reflects the inherent structural flexibility of the IRS. The possible expansion of the site for inhibiting platelet aggregation as proposed previously [Wang et al. (1996), J. Mol. Biol. 255, 669-676] is discussed.
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1IJL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus., Gu L, Zhang H, Song S, Zhou Y, Lin Z, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):104-10. Epub 2001, Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11752784 11752784]
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[[Category: Deinagkistrodon acutus]]
[[Category: Deinagkistrodon acutus]]
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[[Category: Phospholipase A(2)]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Gu L]]
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[[Category: Gu, L.]]
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[[Category: Lin Z]]
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[[Category: Lin, Z.]]
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[[Category: Song S]]
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[[Category: Song, S.]]
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[[Category: Zhang H]]
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[[Category: Zhang, H.]]
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[[Category: Zhou Y]]
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[[Category: Zhou, Y.]]
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[[Category: calcium binding loop]]
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[[Category: one two strand beta sheet]]
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[[Category: three long helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:42 2008''
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Current revision

Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus

PDB ID 1ijl

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